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JA Koufman (1991)
The otolaryngologic manifestations of gastroesophageal reflux diseaseLaryngoscope, 101
M. Groome, J. Cotton, M. Borland, S. Mcleod, D. Johnston, J. Dillon (2007)
Prevalence of Laryngopharyngeal Reflux in a Population With Gastroesophageal RefluxThe Laryngoscope, 117
P. Belafsky, G. Postma, J. Koufman (2001)
The Validity and Reliability of the Reflux Finding Score (RFS)The Laryngoscope, 111
M. Vaezi, D. Hicks, T. Abelson, J. Richter (2003)
Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 1 5
C. Elton, R. Uppal, D. Moore, G. Goldspink, M. Winslet (1999)
Partial cardiomyectomy--an animal model of gastro-oesophageal reflux.International journal of surgical investigation, 1 1
Rintaro Shimazu, K. Kusano, Y. Kuratomi, A. Inokuchi (2009)
Histological changes of the pharynx and larynx in rats with chronic acid reflux esophagitisActa Oto-Laryngologica, 129
A. Vardouniotis, A. Karatzanis, E. Tzortzaki, E. Athanasakis, K. Samara, G. Chalkiadakis, N. Siafakas, G. Velegrakis (2009)
Molecular pathways and genetic factors in the pathogenesis of laryngopharyngeal refluxEuropean Archives of Oto-Rhino-Laryngology, 266
G. Nino, O. Savchenko, Paul Vastola, M. Pagala, Ajay Dhadwal, M. Vaynblat, M. Marcus, M. Kazachkov (2007)
Lipid laden macrophage indices and reflux finding score in canine gastroesophageal reflux modelPediatric Pulmonology, 42
J. Chung, K. Tae, Yong Lee, J. Jeong, S. Cho, Kyung Kim, C. Park, Dong Han (2009)
The Significance of Laryngopharyngeal Reflux in Benign Vocal Mucosal LesionsOtolaryngology–Head and Neck Surgery, 141
J. Koufman (1991)
The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): A Clinical Investigation of 225 Patients Using Ambulatory 24‐Hour pH Monitoring and an Experimental Investigation of the Role of Acid and Pepsin in the Development of Laryngeal InjuryThe Laryngoscope, 101
(2008)
Esophagopha- ryngeal reflux
EV Gaia Filho, A Goldenberg, HO Costa (2005)
Experimental model of gastroesophageal reflux in ratsActa Cir Bras, 20
Jacob Cohen, Kevin Bach, G. Postma, J. Koufman (2002)
Clinical manifestations of laryngopharyngeal reflux.Ear, nose, & throat journal, 81 9 Suppl 2
T. Muderris, M. Gokcan, I. Yorulmaz (2009)
The clinical value of pharyngeal pH monitoring using a double-probe, triple-sensor catheter in patients with laryngopharyngeal reflux.Archives of otolaryngology--head & neck surgery, 135 2
F. Farrokhi, Mf Vaezi (2007)
Extra-esophageal manifestations of gastroesophageal reflux.Oral diseases, 13 4
L. Jonaitis, R. Pribuisiene, L. Kupčinskas, V. Uloza (2006)
Laryngeal examination is superior to endoscopy in the diagnosis of the laryngopharyngeal form of gastroesophageal reflux diseaseScandinavian Journal of Gastroenterology, 41
Y. Lai, Pa-Chun Wang, Jun-Chen Lin (2008)
Laryngopharyngeal reflux in patients with reflux esophagitis.World journal of gastroenterology, 14 28
C. Qua, C. Wong, K. gopala, K. Goh (2006)
Gastro‐oesophageal reflux disease in chronic laryngitis: prevalence and response to acid‐suppressive therapyAlimentary Pharmacology & Therapeutics, 25
Roy Wong, David Hanson, Patrick Waring, Gary Shaw (2000)
ENT manifestations of gastroesophageal reflux.The American journal of gastroenterology, 95 8 Suppl
Edmilson Filho, A. Goldenberg, Henrique Costa (2005)
Experimental model of gastroesophageal reflux in rats 1 Modelo experimental de refluxo gastroesofágico em ratos
Reena Gupta, R. Sataloff (2009)
Laryngopharyngeal reflux: current concepts and questionsCurrent Opinion in Otolaryngology & Head and Neck Surgery, 17
The role of lower esophageal sphincter (LES) in laryngopharyngeal reflux is controversial. In this study, we used an animal model to investigate the association between LES dysfunction and reflux laryngitis. Twelve healthy New Zealand albino rabbits (2.5–3.5 kg) were utilized in this study. The animals were divided into two groups. Eight rabbits underwent total cardiomyectomy to induce reflux, and the remaining four rabbits underwent a control sham operation. A laryngoscopy and a 24-hour intra-esophageal pH-metry were performed prior to surgery and again 2 and 8 weeks postsurgery. After the final laryngoscopy, all animals were sacrificed to obtain histological results. Total cardiomyectomy significantly increased the reflux index, the duration of the longest reflux episode and the total number of episodes that occurred in 24 h postsurgery. No significant difference was observed in the reflux finding score (RFS) between preoperative and 2-week postoperative rabbits ( P = 0.11). But there was a statistically significant change in the RFS before and 8 weeks after the induction of reflux from 4.6 ± 0.9 to 8.3 ± 3.6 ( P = 0.02). Submucous gland hyperplasia and inflammation were significantly increased in the reflux group compared to the control group. The results of this study suggest that chronic lower esophageal sphincter dysfunction is associated with reflux laryngitis in rabbits.
European Archives of Oto-Rhino-Laryngology – Springer Journals
Published: Aug 1, 2012
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