Lactose Intolerance and Other Disaccharidase Deficiency

Lactose Intolerance and Other Disaccharidase Deficiency Intolerance to foods which contain lactose can cause a range of intestinal and systemic symptoms. These symptoms are caused by Lactase deficiency which is encoded by a single gene ( LCT ) of ≈ 50 kb located on chromosome 2q21. In some food items, lactose has been missed because of “hidden” lactose due to inadequately labeled, confusing diagnosis of lactose intolerance based on dietary restriction of dairy foods. Two polymorphisms, C/T13910 and G/A22018, linked to hypolactasia, correlate with breath hydrogen and symptoms after lactose. The key in the management of lactose intolerance is the dietary removal of lactose. Patients diagnosed as lactose intolerant must be advised of “risk” foods, inadequately labeled, including processed meats, bread, cake mixes, soft drinks, and lagers. This review highlights the types, symptoms and management of lactose intolerance and also highlights differences from milk allergy which closely mimics the symptoms of lactose intolerance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Pediatrics Springer Journals

Lactose Intolerance and Other Disaccharidase Deficiency

Indian Journal of Pediatrics, Volume 81 (9) – Sep 1, 2014

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Dr. K C Chaudhuri Foundation
Subject
Medicine & Public Health; Pediatrics; Gynecology
ISSN
0019-5456
eISSN
0973-7693
DOI
10.1007/s12098-014-1346-2
pmid
24596060
Publisher site
See Article on Publisher Site

Abstract

Intolerance to foods which contain lactose can cause a range of intestinal and systemic symptoms. These symptoms are caused by Lactase deficiency which is encoded by a single gene ( LCT ) of ≈ 50 kb located on chromosome 2q21. In some food items, lactose has been missed because of “hidden” lactose due to inadequately labeled, confusing diagnosis of lactose intolerance based on dietary restriction of dairy foods. Two polymorphisms, C/T13910 and G/A22018, linked to hypolactasia, correlate with breath hydrogen and symptoms after lactose. The key in the management of lactose intolerance is the dietary removal of lactose. Patients diagnosed as lactose intolerant must be advised of “risk” foods, inadequately labeled, including processed meats, bread, cake mixes, soft drinks, and lagers. This review highlights the types, symptoms and management of lactose intolerance and also highlights differences from milk allergy which closely mimics the symptoms of lactose intolerance.

Journal

Indian Journal of PediatricsSpringer Journals

Published: Sep 1, 2014

References

  • Lactose intolerance
    Vesa, TH; Marteaue, P; Korpela, R
  • Lactose intolerance in clinical practice- Myths and realities
    Lomer, MCE; Parkes, GC; Sanderson, JD

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