213 118 118 4 4 T. H. Privette D. M. Terrian Department of Anatomy and Cell Biology East Carolina University School of Medicine 27858-4354 Greenville North Carolina USA Abstract The selective k agonist U-50,488H was evaluated on the elevated plus-maze test of anxiety. U-50,488H was administered intraperitoneally to male Sprague-Dawley rats 20 min before testing, first in an open field apparatus, then followed immediately on the elevated plus-maze. No significant change in spontaneous locomotor activity was measured in the open field apparatus, suggesting that U-50,488H was devoid of sedative effects in the dose range tested (0.1–1000 µg/kg, IP). Doses between 10 and 1000 µg/kg produced significant increases in elevated plus-maze behavior that were consistent with anxiolytic actions for U-50,488H. These anxiolytic-like effects were antagonized by naloxone (2.0 mg/kg, IP), suggesting an opioid receptor site of action. In addition, we tested the k 1 -selective U-50,488H-derivative, U-69,593 (100 µg/kg, IP), which was also shown to mimic the anxiolytic-like effects produced by U-50,488H. These results suggest that low doses of the selective k 1 agonists U-50,488H and U-69,593 are endowed with anxiolytic properties in rodents and that the k opioid system may be involved in the behavioral response to anxiety.
Psychopharmacology – Springer Journals
Published: Apr 1, 1995
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