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Isolation of a dihydrobenzofuran lignan, icariside E 4 , with an antinociceptive effect from Tabebuia roseo - alba (Ridley) Sandwith (Bignoniaceae) bark

Isolation of a dihydrobenzofuran lignan, icariside E 4 , with an antinociceptive effect from... The antinociceptive activity of icariside E 4 , a dihydrobenzofuran-type lignan isolated from Tabebuia roseo - alba (Ridley) Sandwith (Bignoniaceae) bark, was evaluated in mice by using chemical and thermal models of nociception. Intraperitoneal (i.p.) administration of crude T. roseo - alba bark extract and its methanol fraction inhibited acetic acid-induced abdominal constriction in mice. Furthermore, i.p. administration of 0.1, 1, and 10 mg/kg of icariside E 4 reduced the number of writhes evoked by acetic acid injection by 46.9, 82.3, and 66.6 %, respectively. Icariside E 4 administration had no effect in the first phase of the formalin test, but it reduced nociceptive behavior in the second phase as indicated by a reduction in the licking time. Icariside E 4 did not modify thermal nociception in the hot-plate test model, suggesting that it had a peripheral antinociceptive action. The antinociceptive effect of icariside E 4 in the writhing test was reversed by pre-administration of glibenclamide, but not of naloxone, atropine, yohimbine, or haloperidol. Together, these results indicated that the antinociceptive activity of icariside E 4 from T. roseo - alba in models of chemical pain occurred through ATP-sensitive K + channel-dependent mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pharmacal Research Springer Journals

Isolation of a dihydrobenzofuran lignan, icariside E 4 , with an antinociceptive effect from Tabebuia roseo - alba (Ridley) Sandwith (Bignoniaceae) bark

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References (28)

Publisher
Springer Journals
Copyright
Copyright © 2015 by The Pharmaceutical Society of Korea
Subject
Pharmacy; Pharmacy; Pharmacology/Toxicology
ISSN
0253-6269
eISSN
1976-3786
DOI
10.1007/s12272-014-0468-4
pmid
25138119
Publisher site
See Article on Publisher Site

Abstract

The antinociceptive activity of icariside E 4 , a dihydrobenzofuran-type lignan isolated from Tabebuia roseo - alba (Ridley) Sandwith (Bignoniaceae) bark, was evaluated in mice by using chemical and thermal models of nociception. Intraperitoneal (i.p.) administration of crude T. roseo - alba bark extract and its methanol fraction inhibited acetic acid-induced abdominal constriction in mice. Furthermore, i.p. administration of 0.1, 1, and 10 mg/kg of icariside E 4 reduced the number of writhes evoked by acetic acid injection by 46.9, 82.3, and 66.6 %, respectively. Icariside E 4 administration had no effect in the first phase of the formalin test, but it reduced nociceptive behavior in the second phase as indicated by a reduction in the licking time. Icariside E 4 did not modify thermal nociception in the hot-plate test model, suggesting that it had a peripheral antinociceptive action. The antinociceptive effect of icariside E 4 in the writhing test was reversed by pre-administration of glibenclamide, but not of naloxone, atropine, yohimbine, or haloperidol. Together, these results indicated that the antinociceptive activity of icariside E 4 from T. roseo - alba in models of chemical pain occurred through ATP-sensitive K + channel-dependent mechanisms.

Journal

Archives of Pharmacal ResearchSpringer Journals

Published: Jun 1, 2015

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