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A. Philchenkov (2004)
Caspases: potential targets for regulating cell deathJournal of Cellular and Molecular Medicine, 8
Markus Grütter (2000)
Caspases: key players in programmed cell death.Current opinion in structural biology, 10 6
A. Alimonti, A. Gelibter, I. Pavese, F. Satta, F. Cognetti, G. Ferretti, D. Rasio, A. Vecchione, M. Palma (2004)
New approaches to prevent intestinal toxicity of irinotecan-based regimens.Cancer treatment reviews, 30 6
D. Keefe (2004)
Gastrointestinal mucositis: a new biological modelSupportive Care in Cancer, 12
A. Russo, S. Corsale, P. Cammareri, V. Agnese, S. Cascio, G. Fede, M. Macaluso, V. Bazan (2005)
Pharmacogenomics in colorectal carcinomas: Future perspectives in personalized therapyJournal of Cellular Physiology, 204
ST Sonis, LS Elting, D Keefe, DE Peterson, M Schubert, M Hauer-Jensen (2004)
Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patientsCancer, 100
Dorothy Keefe, Rachel Gibson, Martin Hauer-Jensen (2004)
Gastrointestinal mucositis.Seminars in oncology nursing, 20 1
T. Scheinin, T. Böhling, L. Halme, S. Kontiainen, L. Bjørge, S. Meri (1999)
Decreased expression of protectin (CD59) in gut epithelium in ulcerative colitis and Crohn's disease.Human pathology, 30 12
E. Marshman, P. Ottewell, C. Potten, A. Watson (2001)
Caspase activation during spontaneous and radiation‐induced apoptosis in the murine intestineThe Journal of Pathology, 195
J. Bowen, R. Gibson, D. Keefe, A. Cummins (2005)
Cytotoxic chemotherapy upregulates pro‐apoptotic Bax and Bak in the small intestine of rats and humansPathology, 37
G. Smyth (2004)
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray ExperimentsStatistical Applications in Genetics and Molecular Biology, 3
G. Cairo, A. Pietrangelo (1995)
Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation.European journal of biochemistry, 232 2
I. Lavrik, Alexander Golks, P. Krammer (2005)
Caspases: pharmacological manipulation of cell death.The Journal of clinical investigation, 115 10
Edward Rubenstein, Douglas Peterson, M. Schubert, D. Keefe, Deborah McGuire, Joel Epstein, Linda Elting, Philip Fox, C. Cooksley, Stephen Sonis (2004)
Mucositis: Perspectives and Clinical Practice Guidelines
M. Bruno, C. Kaetzel (2005)
Long-Term Exposure of the HT-29 Human Intestinal Epithelial Cell Line to TNF Causes Sustained Up-Regulation of the Polymeric Ig Receptor and Proinflammatory Genes through Transcriptional and Posttranscriptional Mechanisms1The Journal of Immunology, 174
Jinsheng Yu, W. Shannon, M. Watson, H. McLeod (2005)
Gene Expression Profiling of the Irinotecan Pathway in Colorectal CancerClinical Cancer Research, 11
Shousong Cao, Jennifer Black, Anthony Troutt, Y. Rustum (1998)
Interleukin 15 offers selective protection from irinotecan-induced intestinal toxicity in a preclinical animal model.Cancer research, 58 15
K. Takasuna, T. Hagiwara, M. Hirohashi, Michiyuki Kato, M. Nomura, E. Nagai, T. Yokoi, T. Kamataki (1996)
Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats.Cancer research, 56 16
D. Keefe, J. Brealey, G. Goland, A. Cummins (2000)
Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humansGut, 47
Stephen Sonis, J. Scherer, S. Phelan, C. Lucey, J. Barron, K. O'Donnell, Richard Brennan, H. Pan, Paul Busse, J. Haley (2002)
The gene expression sequence of radiated mucosa in an animal mucositis modelCell Proliferation, 35
F. Morvan, B. Baroukh, D. Ledoux, J. Caruelle, D. Barritault, G. Godeau, J. Saffar (2004)
An engineered biopolymer prevents mucositis induced by 5-fluorouracil in hamsters.The American journal of pathology, 164 2
S. Sonis (2004)
A biological approach to mucositis.The journal of supportive oncology, 2 1
Y. Shibata, H. Takiguchi, K. Tamura, K. Yamanaka, M. Tezuka, Y. Abiko (1996)
Stimulation of Interleukin-1β-Converting Enzyme Activity during Growth Inhibition by CPT-11 in the Human Myeloid Leukemia Cell Line K562Biochemical and Molecular Medicine, 57
Ingrid Lönnstedt (2001)
Replicated microarray dataStatistica Sinica, 12
S. Kondo, B. Barna, T. Morimura, J. Takeuchi, J. Yuan, A. Akbaşak, G. Barnett (1995)
Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.Cancer research, 55 24
Q. Chu, L. Hammond, G. Schwartz, L. Ochoa, S. Rha, L. Denis, K. Molpus, B. Roedig, S. Letrent, B. Damle, A. DeCillis, E. Rowinsky (2004)
Phase I and Pharmacokinetic Study of the Oral Fluoropyrimidine S-1 on a Once-Daily-for-28-Day Schedule in Patients with Advanced MalignanciesClinical Cancer Research, 10
S. Kondo, B. Barna, T. Morimura, J. Takeuchi, Junying Yuan, A. Akbaşak, G. Barnett (1995)
Interleukin-1β-converting Enzyme Mediates Cisplatin-induced Apoptosis in Malignant Glioma CellsCancer Research, 55
M Edwards, R. Wenstrup, P. Byers, D. Cohn, G Wallis, B. Starman, A. Zinn, N Fedarko, M. Moerike, R. Brenner, P. Robey, U. Vetter, J. Bone, Miner, N Inoue, R. Hirata, D. Russell, R. Dong, Mol, S. Altmann, H. Davis, Li‐ji Zhu, X. Yao, L. Hoos, G. Tetzloff, Sai Prasad, N. Iyer, M. Maguire, A. Golovko, Ming Zeng, Luquan Wang, N. Murgolo, M. Graziano
Materials and Methods Figs. S1 to S4 Tables S1 and S2 References Niemann-pick C1 like 1 Protein Is Critical for Intestinal Cholesterol Absorption
Ingrid Lönnstedt, T. Britton (2005)
Hierarchical Bayes models for cDNA microarray gene expression.Biostatistics, 6 2
S. Sonis (2004)
The pathobiology of mucositisNature Reviews Cancer, 4
R. Gibson, D. Keefe, J. Clarke, G. Regester, F. Thompson, G. Goland, B. Edwards, A. Cummins (2002)
The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancerCancer Chemotherapy and Pharmacology, 50
J. Yang, Michael Buckley, T. Speed (2001)
Analysis of CDNA Microarray ImagesBriefings in bioinformatics, 2 4
A. Jarry, G. Vallette, Elisabeth Cassagnau, A. Moreau, C. Bou‐Hanna, P. Lemarre, E. Letessier, J. Neel, J. Galmiche, C. Laboisse (1999)
Interleukin 1 and interleukin 1β converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancerGut, 45
C. Katona, J. Kralovánszky, A. Rosta, E. Pandi, G. Fónyad, K. Tóth, A. Jeney (1998)
Putative Role of Dihydropyrimidine Dehydrogenase in the Toxic Side Effect of 5-Fluorouracil in Colorectal Cancer PatientsOncology, 55
Daniele Morelli, Sylvie Ménard, Maria Colnaghi, Andrea Balsari (1996)
Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice.Cancer research, 56 9
C. Tran, G. Howarth, P. Coyle, J. Philcox, A. Rofe, R. Butler (2003)
Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine.The American journal of clinical nutrition, 77 5
R. Gibson, D. Keefe, F. Thompson, J. Clarke, G. Goland, A. Cummins (2002)
Effect of Interleukin-11 on Ameliorating Intestinal Damage After Methotrexate Treatment of Breast Cancer in RatsDigestive Diseases and Sciences, 47
Martin Johnson, Alexander Hageboutros, Kangsheng Wang, Lisa High, Jeffrey Smith, R. Diasio (1999)
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.Clinical cancer research : an official journal of the American Association for Cancer Research, 5 8
S. Schreiber, R. Macdermott, A. Raedler, R. Pinnau, M. Bertovich, G. Nash (1991)
Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease.Gastroenterology, 101 4
R. Gibson, J. Bowen, M. Inglis, A. Cummins, D. Keefe (2003)
Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancerJournal of Gastroenterology and Hepatology, 18
Y. Ando, Y. Hasegawa (2005)
Clinical Pharmacogenetics of Irinotecan (CPT-11)Drug Metabolism Reviews, 37
J. Pico, Andrés Avila‐Garavito, P. Naccache (1998)
Mucositis: Its Occurrence, Consequences, and Treatment in the Oncology Setting.The oncologist, 3 6
A. Väkevä, P. Laurila, S. Meri (1992)
Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction.Laboratory investigation; a journal of technical methods and pathology, 67 5
D. Barisani, A. Parafioriti, M. Bardella, H. Zoller, D. Conte, E. Armiraglio, C. Trovato, R. Koch, G. Weiss (2004)
Adaptive changes of duodenal iron transport proteins in celiac disease.Physiological genomics, 17 3
SW Altmann, HR Davis, LJ Zhu, X Yao, LM Hoos, G Tetzloff (2004)
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorptionScience, 303
S. Launay, O. Hermine, M. Fontenay, G. Kroemer, E. Solary, C. Garrido (2005)
Vital functions for lethal caspasesOncogene, 24
M. Lamkanfi, M. Kalai, X. Saelens, W. Declercq, P. Vandenabeele (2004)
Caspase-1 Activates Nuclear Factor of the κ-Enhancer in B Cells Independently of Its Enzymatic Activity*Journal of Biological Chemistry, 279
R. Gibson, J. Bowen, D. Keefe (2005)
Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor‐bearing DA ratsInternational Journal of Cancer, 116
E. Creagh, H. Conroy, Seamus Martin (2003)
Caspase‐activation pathways in apoptosis and immunityImmunological Reviews, 193
R. Boushey, B. Yusta, D. Drucker (2001)
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.Cancer research, 61 2
F. Martinon, J. Tschopp (2004)
Inflammatory Caspases Linking an Intracellular Innate Immune System to Autoinflammatory DiseasesCell, 117
N. Ikuno, H. Soda, M. Watanabe, M. Oka (1995)
Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum.Journal of the National Cancer Institute, 87 24
ST Sonis (2004)
Pathobiology of mucositisSemin Oncol Nurs, 20
T. Mulder, A. Veer, H. Verspaget, G. Griffioen, A. Peña, A. Janssens, C. Lamers (1994)
Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel diseaseJournal of Gastroenterology and Hepatology, 9
This study has identified MAP kinase signalling as being involved with irinotecan-induced intestinal damage and confirms previous findings with radiation-induced oral mucosal damage, which also implicated this pathway. Microarrays are emerging as a valuable tool in mucositis research by linking such findings. The common pathway of chemotherapy- and radiotherapy-induced damage, which utilises the caspase-cascade, may be a useful target to prevent apoptosis following cancer treatment.
Cancer Chemotherapy and Pharmacology – Springer Journals
Published: Mar 1, 2007
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