Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with amphetamine

Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with... 221 91 91 2 2 D. N. Abrous E. M. Torres L. E. Annett P. J. Reading S. B. Dunnett Department of Experimental Psychology University of Cambridge Downing Street CB23EB Cambridge UK Summary The aim of the present experiment was to characterize the effect of intrastriatal grafts of embryonic dopaminergic neurones on the expression of Fos protein in the striatum when challenged with amphetamine. Unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway were made in adult rats and grafting was performed 3 weeks later. The numbers of Fos-positive nuclei in the ipsi- and contralateral striata were counted on coronal sections following immunohistochemical staining 5 months after grafting. Administration of d -amphetamine induced an increase in the density of Fospositive nuclei in the intact striatum. This stimulatory effect of amphetamine on c-fos expression was blocked by 6-hydroxydopamine hydrobromide lesions and was restored in the striata bearing transplants. However, an overshoot was observed as the density of Fos-positive cells within the grafted striatum was larger than that observed within the intact striatum. This hyperexpression of Fos-positive nuclei was correlated with the exaggerated compensation of amphetamine-induced rotation in the same animals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with amphetamine

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Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
D.O.I.
10.1007/BF00231653
Publisher site
See Article on Publisher Site

Abstract

221 91 91 2 2 D. N. Abrous E. M. Torres L. E. Annett P. J. Reading S. B. Dunnett Department of Experimental Psychology University of Cambridge Downing Street CB23EB Cambridge UK Summary The aim of the present experiment was to characterize the effect of intrastriatal grafts of embryonic dopaminergic neurones on the expression of Fos protein in the striatum when challenged with amphetamine. Unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway were made in adult rats and grafting was performed 3 weeks later. The numbers of Fos-positive nuclei in the ipsi- and contralateral striata were counted on coronal sections following immunohistochemical staining 5 months after grafting. Administration of d -amphetamine induced an increase in the density of Fospositive nuclei in the intact striatum. This stimulatory effect of amphetamine on c-fos expression was blocked by 6-hydroxydopamine hydrobromide lesions and was restored in the striata bearing transplants. However, an overshoot was observed as the density of Fos-positive cells within the grafted striatum was larger than that observed within the intact striatum. This hyperexpression of Fos-positive nuclei was correlated with the exaggerated compensation of amphetamine-induced rotation in the same animals.

Journal

Experimental Brain ResearchSpringer Journals

Published: Oct 1, 1992

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