Intermittent exercise improves working memory and locomotor activity by attenuating oxidative stress in the prefrontal cortex and cerebellum of ovariectomized rats

Intermittent exercise improves working memory and locomotor activity by attenuating oxidative... Objectives The aim of the present study was to investigate the effects of moderate- or high-intensity intermittent exercise (MIIE/HIIE) on the oxidative status of the prefrontal cortex and cerebellum, locomotor activities, as well as working memory performances of rats. Materials and Methods Twenty female rats were divided into four groups: (1) sham-operated (Sham), (2) ovariectomy (OVX), (3) OVX + MIIE, and (4) OVX + HIIE groups. The OVX + MIIE and OVX + HIIE groups exercised on a rat tread- mill for 7 weeks. The assessment on the working memory performances and locomotor activities were conducted on the last day of the exercise period. Levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activities, as well as levels of hydrogen peroxidase (H O ), and malondialdehyde (MDA) in the prefrontal cortex 2 2 and cerebellum were determined using a spectrophotometer. Results Ovariectomy depressed the working memory, locomotor activities, the levels of SOD, CAT, and GPX enzyme activities, and elevated the levels of H O , and MDA in the prefrontal cortex and cerebellum. 2 2 Conclusion MIIE and HIIE exert their neuroprotective effects by reducing oxidative stress in the brain of ovariectomized rats. HIIE has more potent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sport Sciences for Health Springer Journals

Intermittent exercise improves working memory and locomotor activity by attenuating oxidative stress in the prefrontal cortex and cerebellum of ovariectomized rats

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Publisher
Springer Milan
Copyright
Copyright © 2018 by Springer-Verlag Italia S.r.l., part of Springer Nature
Subject
Medicine & Public Health; Sports Medicine; Human Physiology; Metabolic Diseases
ISSN
1824-7490
eISSN
1825-1234
D.O.I.
10.1007/s11332-018-0470-1
Publisher site
See Article on Publisher Site

Abstract

Objectives The aim of the present study was to investigate the effects of moderate- or high-intensity intermittent exercise (MIIE/HIIE) on the oxidative status of the prefrontal cortex and cerebellum, locomotor activities, as well as working memory performances of rats. Materials and Methods Twenty female rats were divided into four groups: (1) sham-operated (Sham), (2) ovariectomy (OVX), (3) OVX + MIIE, and (4) OVX + HIIE groups. The OVX + MIIE and OVX + HIIE groups exercised on a rat tread- mill for 7 weeks. The assessment on the working memory performances and locomotor activities were conducted on the last day of the exercise period. Levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activities, as well as levels of hydrogen peroxidase (H O ), and malondialdehyde (MDA) in the prefrontal cortex 2 2 and cerebellum were determined using a spectrophotometer. Results Ovariectomy depressed the working memory, locomotor activities, the levels of SOD, CAT, and GPX enzyme activities, and elevated the levels of H O , and MDA in the prefrontal cortex and cerebellum. 2 2 Conclusion MIIE and HIIE exert their neuroprotective effects by reducing oxidative stress in the brain of ovariectomized rats. HIIE has more potent

Journal

Sport Sciences for HealthSpringer Journals

Published: May 29, 2018

References

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