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Interaction between d -amphetamine and ethanol with respect to locomotion, stereotypies, ethanol sleeping time, and the kinetics of drug elimination

Interaction between d -amphetamine and ethanol with respect to locomotion, stereotypies, ethanol... 213 59 59 2 2 I. Todzy H. Coper M. Fernandes Institute of Neuropsychopharmacology Free University Berlin Ulmenallee 30 D-1000 Berlin 19 Abstract The interaction between d -amphetamine and ethanol with respect to locomotor activity, stereotyped behavior, and sleeping time was investigated in rats. Ethanol 0.8 g/kg i.p. enhanced and prolonged locomotor activity produced by d -amphetamine 1 mg/kg s.c. The increased motility after 5 mg/kg d -amphetamine was not influenced by alcohol 0.8 g/kg i.p. or 3.2 g/kg orally, but slightly protracted. Stereotyped head and paw movements as well as stereotyped licking, were distinctly strengthened and protracted by 3.2 g/kg ethanol orally. The modified d -amphetamine motility and stereotypies can be explained by alcohol-induced prolongation of the life of d -amphetamine. The effect is produced by alcohol's inhibition d -amphetamine p-hydroxylation in rat liver. After 3.2 g/kg ethanol i.p., the sleeping time of male rats amounted to 153 min. Simultaneous administration of 5 mg/kg d -amphetamine s.c. reduced the sleeping time to 84 min. This is obviously based on a central antagonism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Interaction between d -amphetamine and ethanol with respect to locomotion, stereotypies, ethanol sleeping time, and the kinetics of drug elimination

Todzy, I.; Coper, H.; Fernandes, M.
Psychopharmacology , Volume 59 (2) – Jan 1, 1978
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References (23)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00427748
Publisher site
See Article on Publisher Site

Abstract

213 59 59 2 2 I. Todzy H. Coper M. Fernandes Institute of Neuropsychopharmacology Free University Berlin Ulmenallee 30 D-1000 Berlin 19 Abstract The interaction between d -amphetamine and ethanol with respect to locomotor activity, stereotyped behavior, and sleeping time was investigated in rats. Ethanol 0.8 g/kg i.p. enhanced and prolonged locomotor activity produced by d -amphetamine 1 mg/kg s.c. The increased motility after 5 mg/kg d -amphetamine was not influenced by alcohol 0.8 g/kg i.p. or 3.2 g/kg orally, but slightly protracted. Stereotyped head and paw movements as well as stereotyped licking, were distinctly strengthened and protracted by 3.2 g/kg ethanol orally. The modified d -amphetamine motility and stereotypies can be explained by alcohol-induced prolongation of the life of d -amphetamine. The effect is produced by alcohol's inhibition d -amphetamine p-hydroxylation in rat liver. After 3.2 g/kg ethanol i.p., the sleeping time of male rats amounted to 153 min. Simultaneous administration of 5 mg/kg d -amphetamine s.c. reduced the sleeping time to 84 min. This is obviously based on a central antagonism.

Journal

Psychopharmacology – Springer Journals

Published: Jan 1, 1978

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