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K. Tötterman, L. Groop, Per-Henrik Groop, R. Kala, E. Tolppanen, Frej Fyhrquist (2004)
Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patientsEuropean Journal of Clinical Pharmacology, 26
G. Shulman, D. Rothman, T. Jue, P. Stein, R. DeFronzo, R. Shulman (1990)
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.The New England journal of medicine, 322 4
P. Morales, B. Mitchell, R. Valdez, H. Hazuda, M. Stern, S. Haffner (1993)
Incidence of NIDDM and Impaired Glucose Tolerance in Hypertensive Subjects: The San Antonio Heart StudyDiabetes, 42
Peter Arner, T. Pollare, H. Lithell (1991)
Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjectsDiabetologia, 34
C. Catalano, P. Winocour, T. Thomas, M. Walker, C. Sum, R. Wilkinson, K. Alberti (2004)
Erythrocyte sodium-lithium countertransport activity and total body insulin-mediated glucose disposal in normoalbuminuric normotensive Type 1 (insulin-dependent) diabetic patientsDiabetologia, 36
J., Radziuk, K., H., Norwich (1978)
Experimental validation of measurements of glucose turnover in nonsteady state.The American journal of physiology, 234 1
L. Groop, R. Bonadonna, S. Delprato, K. Ratheiser, Kathy Zyck, E. Ferrannini, R. DeFronzo (1989)
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.The Journal of clinical investigation, 84 1
E. Ferrannini, G. Buzzigoli, R. Bonadonna, M. Giorico, M. Oleggini, L. Graziadei, R. Pedrinelli, L. Brandi, S. Bevilacqua (1987)
Insulin resistance in essential hypertension.The New England journal of medicine, 317 6
G. Viberti, R. Jarrett, U. Mahmud, R. Hill, A. Argyropoulos, H. Keen (1982)
MICROALBUMINURIA AS A PREDICTOR OF CLINICAL NEPHROPATHY IN INSULIN-DEPENDENT DIABETES MELLITUSThe Lancet, 319
J. Faria, Sharon Jones, F. Macdonald, J. Chambers, M. Mattock, G. Viberti (1992)
Sodium-Lithium Countertransport Activity and Insulin Resistance in Normotensive IDDM PatientsDiabetes, 41
A. Teppo, L. Groop (1985)
Urinary Excretion of Plasma Proteins in Diabetic Subjects: Increased Excretion of Kappa Light Chains in Diabetic Patients With and Without Proliferative RetinopathyDiabetes, 34
C. Mogensen, C. Christensen (1984)
[Predicting diabetic nephropathy].Journees annuelles de diabetologie de l'Hotel-Dieu
L. Resnick (1989)
Hypertension and abnormal glucose homeostasis. Possible role of divalent ion metabolism.The American journal of medicine, 87 6A
R. DeFronzo, J. Tobin, R. Andres (1979)
Glucose clamp technique: a method for quantifying insulin secretion and resistance.The American journal of physiology, 237 3
T. Coleman, R. Manning, R. Norman, A. Guyton (1972)
Dynamics of water-isotope distribution.The American journal of physiology, 223 6
Mauri Laakso, H. Sarlund, L. Mykkänen (1989)
Essential hypertension and insulin resistance in non‐insulin‐dependent diabetesEuropean Journal of Clinical Investigation, 19
A. Schmitz, M. Vaeth (1988)
Microalbuminuria: A Major Risk Factor in Non‐insulin‐dependent Diabetes. A 10‐year Follow‐up Study of 503 PatientsDiabetic Medicine, 5
G. Reaven (1988)
Role of Insulin Resistance in Human DiseaseDiabetes, 37
E. Ferrannini (1988)
The theoretical bases of indirect calorimetry: a review.Metabolism: clinical and experimental, 37 3
(1984)
Microalbu - minuria in non - diabetic first degree relatives of type 2 diabetic patients
M. Mattock, H. Keen, G. Viberti, M. El-Gohari, T. Murrells, G. Scott, J. Wing, P. Jackson (1988)
Coronary heart disease and urinary albumin excretion rate in Type 2 (non-insulin-dependent) diabetic patientsDiabetologia, 31
K. Nørgaard, T. Jensen, B. Feldt-Rasmussen (2004)
Transcapillary escape rate of albumin in hypertensive patients with Type 1 (insulin-dependent) diabetes mellitusDiabetologia, 36
Leo Niskanen, M. Uusitupa, H. Sarlund, O. Siitonen, E. Voutilainen, I. Penttilä, K. Pyörälä (1990)
Microalbuminuria predicts the development of serum lipoprotein abnormalities favouring atherogenesis in newly diagnosed type 2 (non-insulin-dependent) diabetic patientsDiabetologia, 33
C. Stehouwer, G. Zeldenrust, G. Ottolander, W. Hackeng, A. Donker, J. Nauta (1992)
Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitusThe Lancet, 340
M. Roden, K. Petersen, G. Shulman (2016)
Insulin Resistance in Type 2 Diabetes
(1991)
Abnormalities in extrahepatic insulin sensitivity are a peculiar feature of non - insulin dependent diabetic patients with but not without hypertension and / or microalbuminuria
T. Jensen, B. Feldt-Rasmussen, J. Bjerre-Knudsen, T. Deckert (1989)
FEATURES OF ENDOTHELIAL DYSFUNCTION IN EARLY DIABETIC NEPHROPATHYThe Lancet, 333
C. Mogensen (1984)
Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.The New England journal of medicine, 310 6
M. Borkman, L. Storlien, D. Pan, A. Jenkins, D. Chisholm, L. Campbell (1993)
The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids.The New England journal of medicine, 328 4
S. Haffner, M. Stern, M. Gruber, H. Hazuda, B. Mitchell, J. Patterson (1990)
Microalbuminuria. Potential marker for increased cardiovascular risk factors in nondiabetic subjects?Arteriosclerosis, 10 5
D. Shen, S. Shieh, M. Fuh, D. Wu, Ydi Chen, G. Reaven, P. Chu (1988)
Resistance to insulin-stimulated-glucose uptake in patients with hypertension.The Journal of clinical endocrinology and metabolism, 66 3
R. DeFronzo (1988)
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDMDiabetes, 37
T. Pollare, H. Lithell, C. Berne (1989)
A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension.The New England journal of medicine, 321 13
R. Jarrett, G. Viberti, A. Argyropoulos, R. Hill, U. Mahmud, T. Murrells (1984)
Microalbuminuria Predicts Mortality in Noninsulin‐dependent DiabetesDiabetic Medicine, 1
125 36 36 7 7 L. Groop A. Ekstrand C. Forsblom E. Widén P. -H. Groop A. -M. Teppo J. Eriksson Fourth Department of Medicine Helsinki University Hospital Helsinki Finland Summary We examined the impact of hypertension and microalbuminuria on insulin sensitivity in patients with Type 2 (non-insulin-dependent) diabetes mellitus using the euglycaemic insulin clamp technique in 52 Type 2 diabetic patients and in 19 healthy control subjects. Twenty-five diabetic patients had hypertension and 19 had microalbuminuria. Hypertension per se was associated with a 27% reduction in the rate of total glucose metabolism and a 40% reduction in the rate of non-oxidative glucose metabolism compared with normotensive Type 2 diabetic patients (both p<0.001). Glucose metabolism was also impaired in normotensive microalbuminuric patients compared with normotensive normoalbuminuric patients (29.4±2.2 vs 40.5±2.8 μmol · kg lean body mass −1 · min −1 ; p =0.012), primarily due to a reduction in non-oxidative glucose metabolism (12.7±2.9 vs 21.1±2.6 μmol · kg lean body mass −1 ·min −1 ; p =0.06). In a factorial ANOVA design, however, only hypertension ( p =0.008) and the combination of hypertension and microalbuminuria ( p =0.030) were significantly associated with the rate of glucose metabolism. The highest triglyceride and lowest HDL cholesterol concentrations were observed in Type 2 diabetic patients with both hypertension and microalbuminuria. Of note, glucose metabolism was indistinguishable from that in control subjects in Type 2 diabetic patients without hypertension and microalbuminuria (40.5±2.8 vs 44.4±2.8 μmol · kg lean body mass −1 · min −1 ). We conclude that insulin resistance in Type 2 diabetes is predominantly associated with either hypertension or microalbuminuria or with both.
Diabetologia – Springer Journals
Published: Jul 1, 1993
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