Inhibition of d -amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

Inhibition of d -amphetamine-induced locomotor activity by injection of haloperidol into the... 213 41 41 2 2 A. J. J. Pijnenburg W. M. M. Honig J. M. Van Rossum Department of Pharmacology University of Nijmegen Geert Grooteplein Noord 21 Nijmegen The Netherlands Abstract The effect of intracerebral administration of antagonists of dopamine and noradrenaline upon the locomotor stimulation induced by intraperitoneal injection of d -amphetamine sulfate in rats was investigated. Injection of low doses of the dopamine antagonist haloperidol (2.5 Μg and 5 Μg) bilaterally into the nucleus accumbens antagonized the locomotor stimulation following d -amphetamine. No significant inhibition was observed following administration of the alpha-adrenergic antagonist phentolamine or the beta-adrenergic antagonist propranolol into the nucleus accumbens. Injection of the same doses of haloperidol into the caudate nucleus did not inhibit the d -amphetamine induced locomotor activity, in contrast to the effects seen following injection into the nucleus accumbens. The results confirm the significance of dopaminergic mechanisms for the locomotor stimulant effect of d -amphetamine and indicate that the mesolimbic dopamine system plays an important role in this respect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Inhibition of d -amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

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Abstract

213 41 41 2 2 A. J. J. Pijnenburg W. M. M. Honig J. M. Van Rossum Department of Pharmacology University of Nijmegen Geert Grooteplein Noord 21 Nijmegen The Netherlands Abstract The effect of intracerebral administration of antagonists of dopamine and noradrenaline upon the locomotor stimulation induced by intraperitoneal injection of d -amphetamine sulfate in rats was investigated. Injection of low doses of the dopamine antagonist haloperidol (2.5 Μg and 5 Μg) bilaterally into the nucleus accumbens antagonized the locomotor stimulation following d -amphetamine. No significant inhibition was observed following administration of the alpha-adrenergic antagonist phentolamine or the beta-adrenergic antagonist propranolol into the nucleus accumbens. Injection of the same doses of haloperidol into the caudate nucleus did not inhibit the d -amphetamine induced locomotor activity, in contrast to the effects seen following injection into the nucleus accumbens. The results confirm the significance of dopaminergic mechanisms for the locomotor stimulant effect of d -amphetamine and indicate that the mesolimbic dopamine system plays an important role in this respect.

Journal

PsychopharmacologySpringer Journals

Published: Jan 1, 1975

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