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Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys

Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus... These findings suggest that the time of dosing, when held constant in both the monkey and rat studies, produced nearly identical effects despite the subjects' diurnal or nocturnal preference. Importantly, these changes in rhythm occurred in the presence of light, revealing the drug as a powerful zeitgeber in a non-human primate and, by extension, in man. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys

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References (39)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Biomedicine; Psychiatry ; Pharmacology/Toxicology ; Neurosciences
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/s00213-009-1503-x
pmid
19277609
Publisher site
See Article on Publisher Site

Abstract

These findings suggest that the time of dosing, when held constant in both the monkey and rat studies, produced nearly identical effects despite the subjects' diurnal or nocturnal preference. Importantly, these changes in rhythm occurred in the presence of light, revealing the drug as a powerful zeitgeber in a non-human primate and, by extension, in man.

Journal

PsychopharmacologySpringer Journals

Published: Jul 1, 2009

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