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Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers

Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine... Perifosine showed substantial cytotoxic effects in various in vitro models of ovarian cancer. Since anti-tumor effects were not confined to platinum-sensitive cells perifosine seems to be a good candidate for clinical studies in patients especially with platinum resistant ovarian cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Gynecology and Obstetrics Springer Journals

Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Medicine & Public Health; Human Genetics ; Endocrinology; Obstetrics/Perinatology; Gynecology
ISSN
0932-0067
eISSN
1432-0711
DOI
10.1007/s00404-010-1457-6
pmid
20405296
Publisher site
See Article on Publisher Site

Abstract

Perifosine showed substantial cytotoxic effects in various in vitro models of ovarian cancer. Since anti-tumor effects were not confined to platinum-sensitive cells perifosine seems to be a good candidate for clinical studies in patients especially with platinum resistant ovarian cancer.

Journal

Archives of Gynecology and ObstetricsSpringer Journals

Published: Apr 20, 2010

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