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- Publisher
- Springer Journals
- Copyright
- Copyright © 2015 by The Pharmaceutical Society of Korea
- Subject
- Pharmacy; Pharmacy; Pharmacology/Toxicology
- ISSN
- 0253-6269
- eISSN
- 1976-3786
- DOI
- 10.1007/s12272-015-0609-4
- pmid
- 25956697
- Publisher site
- See Article on Publisher Site
Abstract
Sesquiterpene lactone compounds have received considerable attention in pharmacological research due to their therapeutic effects including anti-cancer and anti-inflammatory activities. In this report, we investigated the effect of arsantin, a sesquiterpene lactone compound present in Artemisia santolina , on cellular differentiation in the human promyelocytic leukemia HL-60 cell culture system. Arsantin significantly induced HL-60 cell differentiation in a concentration-dependent manner. Cytofluorometric analysis indicated that arsantin induced HL-60 cell differentiation predominantly into granulocytes. Both PKC and MAPK inhibitors suppressed the HL-60 cell differentiation induced by arsantin. Moreover, treatment with arsantin increased protein levels of PKCα and PKCβII isoforms, and also induced increased protein levels and phosphorylation form of MAPKs in HL-60 cells. Importantly, arsantin synergistically enhanced differentiation of HL-60 cells in a dose-dependent manner when combined with either low doses of 1,25-(OH) 2 D 3 or ATRA. The ability to enhance the differentiation potential of 1,25-(OH) 2 D 3 or ATRA by arsantin may improve outcomes in the therapy of acute promyelocytic leukemia.
Journal
Archives of Pharmacal Research – Springer Journals
Published: Nov 1, 2015