Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?

Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant... 213 115 115 1 2 Gianluigi Tanda Ezio Carboni Roberto Frau Gaetano Di Chiara Department of Toxicology University of Cagliari 09126 Cagliari Italy Abstract Drugs differing in their primary mechanism of action but having in common the ability to act as antidepressants such as fluoxetine (10 mg/kg SC), clomipramine (10 mg/kg IP), imipramine (10 mg/kg IP), desipramine (10 mg/kg IP) and (±)8-OHDPAT (0.03 mg/kg SC) increase extracellular concentrations of dopamine in the rat prefrontal cortex but not in the medial nucleus accumbens. Buspirone (1 mg/kg SC) increased dopamine both in the prefrontal cortex and in the nucleus accumbens. Extracellular 5HT was increased by fluoxetine, clomipramine and imipramine but not by desipramine while 8-OHDPAT and buspirone decreased it. These results raise the possibility that the property of stimulating dopamine transmission in the prefrontal cortex has a role in the antidepressant properties of these drugs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?

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Publisher
Springer Journals
Copyright
Copyright © 1994 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/BF02244785
Publisher site
See Article on Publisher Site

Abstract

213 115 115 1 2 Gianluigi Tanda Ezio Carboni Roberto Frau Gaetano Di Chiara Department of Toxicology University of Cagliari 09126 Cagliari Italy Abstract Drugs differing in their primary mechanism of action but having in common the ability to act as antidepressants such as fluoxetine (10 mg/kg SC), clomipramine (10 mg/kg IP), imipramine (10 mg/kg IP), desipramine (10 mg/kg IP) and (±)8-OHDPAT (0.03 mg/kg SC) increase extracellular concentrations of dopamine in the rat prefrontal cortex but not in the medial nucleus accumbens. Buspirone (1 mg/kg SC) increased dopamine both in the prefrontal cortex and in the nucleus accumbens. Extracellular 5HT was increased by fluoxetine, clomipramine and imipramine but not by desipramine while 8-OHDPAT and buspirone decreased it. These results raise the possibility that the property of stimulating dopamine transmission in the prefrontal cortex has a role in the antidepressant properties of these drugs.

Journal

PsychopharmacologySpringer Journals

Published: Jun 1, 1994

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