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- Publisher
- Springer Journals
- Copyright
- Copyright © 1977 by Springer-Verlag
- Subject
- Biomedicine; Pharmacology/Toxicology; Psychiatry
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- DOI
- 10.1007/BF00426702
- Publisher site
- See Article on Publisher Site
Abstract
213 52 52 3 3 Gerald Gianutsos Kenneth E. Moore Department of Pharmacology Michigan State University 48824 East Lansing Michigan U.S.A. Abstract Baclofen, like γ-butyrolactone, causes a dose-dependent increase in the concentration of dopamine in the mouse brain without affecting the content of norepinephrine. This increase is antagonized by apomorphine. Haloperidol but not pimozide counteracts this effect of apomorphine and dose-dependently enhances the increase in brain dopamine produced by baclofen. The results suggest that baclofen reduces impulse flow in dopaminergic neurons in a manner similar to that produced by γ-butyrolactone.
Journal
Psychopharmacology – Springer Journals
Published: Jan 1, 1977