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Increase in magnesium plasma level after orally administered trimagnesium dicitrate

Increase in magnesium plasma level after orally administered trimagnesium dicitrate 228 49 49 4 4 C. Wilimzig R. Latz W. Vierling E. Mutschler T. Trnovec S. Nyulassy Datapharm GmbH, Planegg Munich Germany Pharmacological Institute Technical University of Munich Biedersteiner Strasse 29 D-80802 Munich Germany Pharmacological Institute University of Frankfurt, Biocenter Niederusel Frankfurt am Main Germany Institute for Preventive and Clinical Medicine University of Bratislava Slovak Republic Abstract Magnesium plasma concentrations were measured in healthy probands before and after administration of trimagnesium dicitrate by the oral and intravenous routes. There was a notable circadian fluctuation of the plasma concentration with a peak in the evening hours. After oral administration of 12 and 24 mmol magnesium, a long-lasting, statistically significant increase in plasma magnesium concentration measured as the increase in area under the curve (AUC) between 0 and 12 h, of 3.1% and 4.6%, respectively, was found. After intravenous administration of 4 and 8 mmol magnesium, AUCs increased by 9.5% and 16.1%, respectively. The decline in the plasma magnesium concentration after i.v. administration was compatible with a three-compartment model with a terminal half-time of about 8 h. Although no absolute value of the oral bioavailability of trimagnesium dicitrate could be determined from the data, our results may be important in helping to elucidate the influence of magnesium preparations on the plasma magnesium concentration. By comparing the effects of different preparations, it should be possible to estimate the relative oral bioavailability and the bioequivalence of these preparations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Increase in magnesium plasma level after orally administered trimagnesium dicitrate

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References (28)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00226334
Publisher site
See Article on Publisher Site

Abstract

228 49 49 4 4 C. Wilimzig R. Latz W. Vierling E. Mutschler T. Trnovec S. Nyulassy Datapharm GmbH, Planegg Munich Germany Pharmacological Institute Technical University of Munich Biedersteiner Strasse 29 D-80802 Munich Germany Pharmacological Institute University of Frankfurt, Biocenter Niederusel Frankfurt am Main Germany Institute for Preventive and Clinical Medicine University of Bratislava Slovak Republic Abstract Magnesium plasma concentrations were measured in healthy probands before and after administration of trimagnesium dicitrate by the oral and intravenous routes. There was a notable circadian fluctuation of the plasma concentration with a peak in the evening hours. After oral administration of 12 and 24 mmol magnesium, a long-lasting, statistically significant increase in plasma magnesium concentration measured as the increase in area under the curve (AUC) between 0 and 12 h, of 3.1% and 4.6%, respectively, was found. After intravenous administration of 4 and 8 mmol magnesium, AUCs increased by 9.5% and 16.1%, respectively. The decline in the plasma magnesium concentration after i.v. administration was compatible with a three-compartment model with a terminal half-time of about 8 h. Although no absolute value of the oral bioavailability of trimagnesium dicitrate could be determined from the data, our results may be important in helping to elucidate the influence of magnesium preparations on the plasma magnesium concentration. By comparing the effects of different preparations, it should be possible to estimate the relative oral bioavailability and the bioequivalence of these preparations.

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Jan 1, 1996

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