125 23 23 3 3 J. Risteli K. E. Draeger G. Regitz H. P. Neubauer Max-Planck-Institut für Biochemie, Martinsried bei München FRG Hoechst AG Frankfurt am Main FRG Department of Clinical Chemistry University of Oulu Finland Summary The serum concentrations of two recently discovered antigens derived from basement membranes (7-S collagen and laminin P2) were assayed in streptozotocin-diabetic rats as possible indicators of basement membrane metabolism. The concentrations of both increased significantly after 8 weeks of diabetes, and that of 7-S collagen at least remained elevated up to 24 weeks. Treatment with insulin, which did not correct the metabolic disturbances, inhibited the increase in the concentration of 7-S collagen in serum, but did not completely normalize that of laminin P2.
Diabetologia – Springer Journals
Published: Sep 1, 1982
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