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Graefes Arch Clin Exp Ophthalmol (2012) 250:297–305 DOI 10.1007/s00417-011-1758-x INFLAMMATORY DISORDERS Identification of immunodominant epitopes of alpha-crystallins recognized by antibodies in sera of patients with uveitis Deshka Doycheva & Beate Preuss & Christoph Deuter & Manfred Zierhut & Reinhild Klein Received: 6 December 2010 /Revised: 3 June 2011 /Accepted: 28 July 2011 /Published online: 13 August 2011 Springer-Verlag 2011 Abstract residues, with an overlap of at least eight amino acids Background A high incidence of autoantibodies to lens each. The synthetic peptides were tested against sera of 110 proteins has been found in sera of patients with uveitis. We patients with different uveitis forms, classified according to showed previously that the anti-lens antibodies reacted anatomical location of intraocular inflammation. predominantly with α-crystallins. The aim of the present Results Four immunodominant regions within the protein study was to identify immunodominant epitopes within the chains of αA- and αB-crystallin could be identified. These protein chains of human αA- and αB-crystallin. regions were recognized by antibodies in sera of 56% of Methods Epitope specificities of antibodies to αA- and αB- uveitis patients. Anti-lens antibodies of IgG-type reacted crystallin were examined by ELISA using synthetic over- preferentially with regions located at amino acid
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: Aug 13, 2011
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