Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man

Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man 125 28 28 11 11 P. Tessari S. Inchiostro G. Biolo E. Duner R. Nosadini A. Tiengo G. Crepaldi Cattedra di Patologia Medica 1a e di Malattie del Ricambio University of Padova Padova Italy Summary To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3±1.0 versus 11.4±0.8mg· kg −1 · min −1 , p <0.01) at comparable insulin concentrations (92±6 versus 93±7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man

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Publisher
Springer Journals
Copyright
Copyright © 1985 by Springer-Verlag
Subject
Medicine & Public Health; Human Physiology; Internal Medicine; Metabolic Diseases
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF00291080
Publisher site
See Article on Publisher Site

Abstract

125 28 28 11 11 P. Tessari S. Inchiostro G. Biolo E. Duner R. Nosadini A. Tiengo G. Crepaldi Cattedra di Patologia Medica 1a e di Malattie del Ricambio University of Padova Padova Italy Summary To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3±1.0 versus 11.4±0.8mg· kg −1 · min −1 , p <0.01) at comparable insulin concentrations (92±6 versus 93±7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels.

Journal

DiabetologiaSpringer Journals

Published: Nov 1, 1985

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