125 28 28 11 11 P. Tessari S. Inchiostro G. Biolo E. Duner R. Nosadini A. Tiengo G. Crepaldi Cattedra di Patologia Medica 1a e di Malattie del Ricambio University of Padova Padova Italy Summary To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3±1.0 versus 11.4±0.8mg· kg −1 · min −1 , p <0.01) at comparable insulin concentrations (92±6 versus 93±7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels.
Diabetologia – Springer Journals
Published: Nov 1, 1985
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