Reactions 1680, p159 - 2 Dec 2017 Hydralazine/magnesium valproate off- label use Skin rash: case report In a study, a patient [age and sex not stated] was described, who developed a skin rash following the off-label use of hydralazine and magnesium valproate [Transkrip; routes and time to reaction onset not stated; not all dosages stated]. The patient was diagnosed with myelodysplastic syndrome (MDS). The patient was started on combination therapy with daily dose hydralazine slow release formulation tablets and magnesium valproate slow release tablets 700mg, 30mg/kg three times daily for myelodysplastic syndrome; both drugs were administered 5 days a week. However, the patient developed a skin rash. The skin rash disappeared without any corrective treatment. Author comment: "The aim of this study is to evaluate the clinical efficacy and safety of hydralazine, [magnesium valproate] in a case series of MDS patients treated in a compassionate manner." "All patients were informed that the administration of this drug combination was off-label". "Most toxicity was transient, grade 1–2, and did not require dose reduction or interruption of treatment." "[O]nly one patient developed a skin rash that disappeared without treatment." Candelaria M, et al. Encouraging results with the compassionate use of hydralazine/valproate (TRANSKRIPTM) as epigenetic treatment for myelodysplastic syndrome (MDS). Annals of Hematology 96: 1825-1832, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1007/s00277-017-3103-x - Mexico 803284622 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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