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Graefes Arch Clin Exp Ophthalmol (2012) 250:185–189 DOI 10.1007/s00417-011-1807-5 RETINAL DISORDERS Homozygosity for the +674C>T polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort Luciana N. Almeida & Rachel Melilo-Carolino & Carlos E. Veloso & Patrícia A. Pereira & Debora M. Miranda & Luiz Armando De Marco & Marcio Bittar Nehemy Received: 1 March 2011 /Revised: 26 June 2011 /Accepted: 15 August 2011 /Published online: 1 September 2011 Springer-Verlag 2011 Abstract for this polymorphism were 3.6 (95%CI 1.6–8.2) for Purpose To investigate the association between VEGF gene homozygous subjects and 1.5 (95%CI 1.1–2.1, P<0.01) if polymorphism and age-related macular degeneration the subject had at least one risk allele. When we studied (AMD) in a Brazilian cohort. separately exudative and dry AMD groups, this polymor- Methods We examined 160 affected individuals and 140 phism was statistically significant for both groups. Con- sex- and age-matched controls recruited at the Vision trolling for CFH and LOC387715 risk genotype the OR Institute and the Retina Department, São Geraldo was 3.0 for VEGF homozygous, and the OR increases if the Hospital, Minas Gerais Federal University, Brazil, patient is homozygous for the three genes. between 2007 and 2011. Genotyping for
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: Sep 1, 2011
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