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Histochemical demonstration of sodium-dependent glutamate uptake in brain tissues by glutamate dehydrogenase reaction

Histochemical demonstration of sodium-dependent glutamate uptake in brain tissues by glutamate... 221 62 62 3 3 G. Wolf G. Schünzel F. Rothe Institute of Biology Medical Academy Magdeburg Erich-Weinert-Str.3 DDR-3014 Magdeburg German Democratic Republic Summary Using a special tetrazolium salt technique, a striking correlation was observed between Na + concentration of the incubation medium and the formation of formazan catalyzed by glutamate dehydrogenase (GDH) in glutaniatergic neuropil areas of the hippocampal formation, cerebellum, and other brain regions. Na + concentrations of 130–150 mmol/l caused maximal formazan production. The GDH catalyzed sodium-dependent increase in formazan production is suggested to be a consequence of the sodium dependence of glutamate uptake in glutaniatergic brain structures supplying the enzyme with substrate. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Histochemical demonstration of sodium-dependent glutamate uptake in brain tissues by glutamate dehydrogenase reaction

Experimental Brain Research , Volume 62 (3) – May 1, 1986

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References (17)

Publisher
Springer Journals
Copyright
Copyright © 1986 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00236047
Publisher site
See Article on Publisher Site

Abstract

221 62 62 3 3 G. Wolf G. Schünzel F. Rothe Institute of Biology Medical Academy Magdeburg Erich-Weinert-Str.3 DDR-3014 Magdeburg German Democratic Republic Summary Using a special tetrazolium salt technique, a striking correlation was observed between Na + concentration of the incubation medium and the formation of formazan catalyzed by glutamate dehydrogenase (GDH) in glutaniatergic neuropil areas of the hippocampal formation, cerebellum, and other brain regions. Na + concentrations of 130–150 mmol/l caused maximal formazan production. The GDH catalyzed sodium-dependent increase in formazan production is suggested to be a consequence of the sodium dependence of glutamate uptake in glutaniatergic brain structures supplying the enzyme with substrate.

Journal

Experimental Brain ResearchSpringer Journals

Published: May 1, 1986

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