Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Hexose transport in epstein-barr virus (EBV) negative lymphoma lines and their EBV converted, virus genome carrying sublines

Hexose transport in epstein-barr virus (EBV) negative lymphoma lines and their EBV converted,... 277 43 43 5 5 W. Siegert T. Mönch III. Medizinische Klinik im Klinikum Großhadern der Ludwig-Maximilians-Universität München Marchioninistraße 15 D-8000 München 70 Federal Republic of Germany Summary Increased hexose uptake is a marker for viral transformation, as has been shown in non-human fibroblasts transformed by oncogenic viruses. If this phenomenon is a general expression of viral induced transformation it should also apply on different oncogenic virus-cell systems. Recently two human EBV-negative lymphoma lines were converted to a stable EBV-positive state by infection with EBV. According to their biochemical and biological properties they enable us to study events associated with EBV-transformation. We analysed the uptake of ( 3 H) glucosamine and ( 3 H) 2-deoxy-D-glucose into BJAB and Ramos and their EBV-converted sublines and found a clear increase of the rate of uptake of both sugars in the EBV-positive sublines. Control experiments confirmed that the increased uptake was due to alterations on the level of the hexose membrane carriers and not due to increased metabolism. The observation of increased hexose uptake in the only presently available virus transformed human cell system is a strong argument for the general importance of this transformation-associated membrane change. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Hematology Springer Journals

Hexose transport in epstein-barr virus (EBV) negative lymphoma lines and their EBV converted, virus genome carrying sublines

Siegert, W.; Mönch, T.
Annals of Hematology , Volume 43 (5) – Nov 1, 1981
Download PDF
9 pages

Loading next page...
 
/lp/springer-journals/hexose-transport-in-epstein-barr-virus-ebv-negative-lymphoma-lines-and-PE8j6iLcxx

References (36)

Publisher
Springer Journals
Copyright
Copyright © 1981 by Springer-Verlag
Subject
Medicine & Public Health; Hematology; Oncology
ISSN
0939-5555
eISSN
1432-0584
DOI
10.1007/BF00320953
Publisher site
See Article on Publisher Site

Abstract

277 43 43 5 5 W. Siegert T. Mönch III. Medizinische Klinik im Klinikum Großhadern der Ludwig-Maximilians-Universität München Marchioninistraße 15 D-8000 München 70 Federal Republic of Germany Summary Increased hexose uptake is a marker for viral transformation, as has been shown in non-human fibroblasts transformed by oncogenic viruses. If this phenomenon is a general expression of viral induced transformation it should also apply on different oncogenic virus-cell systems. Recently two human EBV-negative lymphoma lines were converted to a stable EBV-positive state by infection with EBV. According to their biochemical and biological properties they enable us to study events associated with EBV-transformation. We analysed the uptake of ( 3 H) glucosamine and ( 3 H) 2-deoxy-D-glucose into BJAB and Ramos and their EBV-converted sublines and found a clear increase of the rate of uptake of both sugars in the EBV-positive sublines. Control experiments confirmed that the increased uptake was due to alterations on the level of the hexose membrane carriers and not due to increased metabolism. The observation of increased hexose uptake in the only presently available virus transformed human cell system is a strong argument for the general importance of this transformation-associated membrane change.

Journal

Annals of Hematology – Springer Journals

Published: Nov 1, 1981

There are no references for this article.