Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference

Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference 213 107 107 2 3 Fred O. Risinger Shelly D. Dickinson Christopher L. Cunningham Department of Medical Psychology The Oregon Health Sciences University 3181 SW Sam Jackson Park Road 97201-3098 Portland OR USA Abstract This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP) + ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference

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Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245175
Publisher site
See Article on Publisher Site

Abstract

213 107 107 2 3 Fred O. Risinger Shelly D. Dickinson Christopher L. Cunningham Department of Medical Psychology The Oregon Health Sciences University 3181 SW Sam Jackson Park Road 97201-3098 Portland OR USA Abstract This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP) + ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms.

Journal

PsychopharmacologySpringer Journals

Published: Jun 1, 1992

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