A simple and efficient method for one-pot four-component synthesis of highly functionalized 1,4-dihydropyrano[2,3-c]pyrazoles using hydrazine monohydrate or phenylhydrazine, ethyl acetoacetate, malononitrile and arylaldehydes under solvent-free, thermal conditions, with maltose as catalyst, has been developed. The reaction proceeds smoothly to generate the corresponding product. Use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times, and good yields of the products are the advantages of this method.
Research on Chemical Intermediates – Springer Journals
Published: Sep 3, 2013
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