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Graphene oxide-catalyzed two-step continuous-flow conversion of aryl amine to unsymmetrical thioether

Graphene oxide-catalyzed two-step continuous-flow conversion of aryl amine to unsymmetrical... A sustainable continuous-flow protocol for the conversion of aryl amine to unsymmetrical thioether is described. This technique is a two-step process involving graphene oxide (GO) catalyzed diazotization followed by the reaction with aryl/alkyl thiols. The continuous-flow conditions afford the desired thioethers in very good yields, effectively suppressing formation of possible disulfide, a common by-product in conventional process. The flow reaction is carried out under ambient conditions, applied to a variety of aryl amines and aryl/alkyl thiols and found to be scalable. The catalytic activity of the GO bed under continuous-flow conditions is found within standard time range and recyclable for ten consecutive runs without any loss of its performance.Graphical abstractContinuous-flow technique is applied in graphene oxide (GO) catalyzed conversion of aryl amine to unsymmetrical thioethers.[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Graphene oxide-catalyzed two-step continuous-flow conversion of aryl amine to unsymmetrical thioether

Choudhury, Prasun; Basu, Basudeb
Journal of Flow Chemistry , Volume 10 (2) – Jun 22, 2020
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Publisher
Springer Journals
Copyright
Copyright © Akadémiai Kiadó 2019
Subject
Chemistry; Chemistry/Food Science, general; Green Chemistry; Organic Chemistry; Inorganic Chemistry; Nanochemistry; Industrial Chemistry/Chemical Engineering
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-019-00048-7
Publisher site
See Article on Publisher Site

Abstract

A sustainable continuous-flow protocol for the conversion of aryl amine to unsymmetrical thioether is described. This technique is a two-step process involving graphene oxide (GO) catalyzed diazotization followed by the reaction with aryl/alkyl thiols. The continuous-flow conditions afford the desired thioethers in very good yields, effectively suppressing formation of possible disulfide, a common by-product in conventional process. The flow reaction is carried out under ambient conditions, applied to a variety of aryl amines and aryl/alkyl thiols and found to be scalable. The catalytic activity of the GO bed under continuous-flow conditions is found within standard time range and recyclable for ten consecutive runs without any loss of its performance.Graphical abstractContinuous-flow technique is applied in graphene oxide (GO) catalyzed conversion of aryl amine to unsymmetrical thioethers.[graphic not available: see fulltext]

Journal

Journal of Flow Chemistry – Springer Journals

Published: Jun 22, 2020

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