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Ganglioside G M 1a as inhibitor of Plasmodium falciparum growth in vitro



Blur (1987) 55:127-129 Blut © Springer -Verlag 1987 Letter to the Editors Inhibitor of Plasmodium falciparum Growth in vitro P. Hermentin a, G. Neunziger 1, B. Enders 1, F.R. Seiler 1, and H. Wiegandt 2 1 Behringwerke AG, D-3550 Marburg, Federal Republic of Germany z Department of Physiological Chemistry I, The Philipps-University, D-3550 Marburg, Federal Republic of Germany Ganglioside GMla as Invasion of erythrocytes by malaria parasites involves specific interactions between parasite receptors and erythrocyte ligands [8]. Recent progress in the understanding of the cellular, biochemical and molecular aspects of human red blood cell invasion by Plasmodium falciparum merozoites has come from the suggestion that the red cell sialoglycoproteins, glycophorins A, B and C, may represent receptors of invasion, a hypothesis which has extensively been reviewed [1, 2, 4, 9]. Most recently we have, however, discovered that isolated glycophorin A (GpA) exhibits a toxic effect on the intraerythrocytic growth of Plasmodium falciparum in vitro [5, 6], which has prompted us to revise the current view [3]. We have suggested that toxicity of GpA may be attributable to its hydrophobic portion normally traversing the erythrocyte lipid bilayer [5, 6]. In analogy we have suggested that toxicity of inhibitors that



Annals of HematologySpringer Journals

Published: Aug 1, 1987

DOI: 10.1007/BF00631784

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