Purpose of Review This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. Recent Findings CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometimes better than, dual-energy X-ray absorptiometry areal biomass density (DXA aBMD). There is growing evidence for use of routine CT scans for bone health assessment. Summary CT-based techniques provide a robust approach for osteoporosis diagnosis and fracture prediction. It remains to be seen if further technical advances will improve fracture prediction compared to DXA aBMD. Future work should include more standardization in CTanalyses, establishment of treatment intervention thresholds, and more studies to determine whether routine CT scans can be efficiently used to expand the number of individuals who undergo evaluation for fracture risk. . . . . Keywords Quantitative computed tomography (QCT) Finite element analysis (FEA) Computational anatomy Hip fracture Vertebral fracture Opportunistic CT Introduction Despite the large and growing impact of these fractures, osteoporosis remains underdiagnosed and undertreated Osteoporosis is characterized by reduced bone mass and im- [5–8]. The current clinical standard for assessment of fracture paired bone architecture which lead to fragile bones
Current Osteoporosis Reports – Springer Journals
Published: May 30, 2018
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