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N. Smith, Seungjun Lee, E. Maione, Ronald Roy, S. Mcelligott, K. Shung (2003)
Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs.Ultrasound in medicine & biology, 29 2
J. Tressler, R. Newnham, W. Hughes (1999)
Capped ceramic underwater sound projector: The “cymbal” transducerJournal of the Acoustical Society of America, 105
Samir Mitragotri, David Edwards, David Edwards, D. Blankschtein, Robert Langer (1995)
A mechanistic study of ultrasonically-enhanced transdermal drug delivery.Journal of pharmaceutical sciences, 84 6
J. Tressler, Q. Xu, S. Yoshikawa, K. Uchino, R. Newnham (1994)
Composite flextensional transducers for sensing and actuatingFerroelectrics, 156
Nadine Smith, Seungjun Lee, K. Shung (2003)
Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays.Ultrasound in medicine & biology, 29 8
Y. Sugawara, Katsuhiko Onitsuka, S. Yoshikawa, Qichang Xu, R. Newnham, K. Uchino (1992)
Metal–Ceramic Composite ActuatorsJournal of the American Ceramic Society, 75
Aydin Dogan, Kenji Uchino, R. Newnham (1997)
Composite piezoelectric transducer with truncated conical endcaps "cymbal"IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 44
K. Rolt (1990)
History of the flextensional electroacoustic transducerJournal of the Acoustical Society of America, 87
The goal of this research was the development of a portable therapeutic device for the treatment of diabetes. A 3×3 cymbal array has been successfully tested in noninvasive insulin delivery experiments. The cymbal is a composite flextensional transducer constructed from a poled PZT ceramic and shaped metal endcaps that amplify the transducer motions by two orders of magnitude. Nine cymbals are wired in parallel and potted in polyurethane to form the flat panel arrays. When driven near resonance (20 kHz), the array generated a low intensity acoustic beam of 100 mW/cm2. Animal experiments on hyperglycemic rats and rabbits demonstrated the ultrasonic enhancement of transdermal insulin delivery.
Journal of Materials Science – Springer Journals
Published: Jan 1, 2006
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