Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists

Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists 213 94 94 4 4 Philip Wang Charanjit S. Aulakh James L. Hill Dennis L. Murphy Clinical Neuropharmacology Section, Laboratory of Clinical Science, National Institute of Mental Health NIH Clinical Center, 10-3D41 20892 Bethesda MD USA Abstract The food intake suppressant effects of three serotonin agonists, m -CPP (a selective 5-HT 1B agonist), 8-OHDPAT (a selective 5-HT 1A agonist) and fenfluramine (a 5-HT releasing agent) were compared in three different rat strains: Wistar, Sprague-Dawley (SD) and Fawn-Hooded (FH) rats. Administration of all three serotonin agonists produced dose-dependent decreases in 1 h food intake in all three strains. FH animals were significantly less sensitive to the food intake suppressant effects of all three serotonin agonists than either Wistar or SD rats. Body weight gain over the 9-week course of the study was also significantly less in FH animals than either Wistar or SD animals. These findings support some other data that Fawn Hooded rats, a strain with a peripheral platelet serotonin storage disorder, also possess altered central nervous system serotonergic function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists

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Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00212855
Publisher site
See Article on Publisher Site

Abstract

213 94 94 4 4 Philip Wang Charanjit S. Aulakh James L. Hill Dennis L. Murphy Clinical Neuropharmacology Section, Laboratory of Clinical Science, National Institute of Mental Health NIH Clinical Center, 10-3D41 20892 Bethesda MD USA Abstract The food intake suppressant effects of three serotonin agonists, m -CPP (a selective 5-HT 1B agonist), 8-OHDPAT (a selective 5-HT 1A agonist) and fenfluramine (a 5-HT releasing agent) were compared in three different rat strains: Wistar, Sprague-Dawley (SD) and Fawn-Hooded (FH) rats. Administration of all three serotonin agonists produced dose-dependent decreases in 1 h food intake in all three strains. FH animals were significantly less sensitive to the food intake suppressant effects of all three serotonin agonists than either Wistar or SD rats. Body weight gain over the 9-week course of the study was also significantly less in FH animals than either Wistar or SD animals. These findings support some other data that Fawn Hooded rats, a strain with a peripheral platelet serotonin storage disorder, also possess altered central nervous system serotonergic function.

Journal

PsychopharmacologySpringer Journals

Published: Apr 1, 1988

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