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Fatal legionellosis in patients with malignant hematologic diseases

Fatal legionellosis in patients with malignant hematologic diseases 277 56 56 1 1 D. Schürmann B. Ruf F. Pfannkuch I. Horbach H. D. Pohle II. Medizinische Klinik des Rudolf-Virchow-Krankenhauses Augustenburger Platz 1 D-1000 Berlin 65 Germany Pathologisches Institut des Rudolf-Virchow-Krankenhauses Augustenburger Platz 1 D-1000 Berlin 65 Germany Abteilung für Mikrobiologie des Robert-Koch-Institutes Nordufer 20 D-1000 Berlin 65 Germany Summary Pneumonia was present in 70/157 (44.6%) autopsied patients with malignant hematologic diseases. In 16/70 patients (22.9%), legionellae were found to be the causative agents by screening lung tissue specimens with the direct fluorescent antibody method. In 5/16 patients with Legionella pneumonia, in whom legionellosis had been suspected clinically, the diagnosis had already been established by serology, urinary Legionella antigen detection, and culture. These results provide evidence that legionellosis is an important pneumonia etiology in patients with malignant hematological diseases. Thus, Legionella diagnostics should be applied routinely, and antibiotics effective in the treatment of legionellosis should be added to the usual therapy in patients with etiologically unexplained pneumonias. In view of the common occurrence of relapses of Legionella pneumonia, antibiotic therapy should be continued for an extended period. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Hematology Springer Journals

Fatal legionellosis in patients with malignant hematologic diseases

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References (19)

Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Medicine & Public Health; Hematology; Oncology
ISSN
0939-5555
eISSN
1432-0584
DOI
10.1007/BF00321056
Publisher site
See Article on Publisher Site

Abstract

277 56 56 1 1 D. Schürmann B. Ruf F. Pfannkuch I. Horbach H. D. Pohle II. Medizinische Klinik des Rudolf-Virchow-Krankenhauses Augustenburger Platz 1 D-1000 Berlin 65 Germany Pathologisches Institut des Rudolf-Virchow-Krankenhauses Augustenburger Platz 1 D-1000 Berlin 65 Germany Abteilung für Mikrobiologie des Robert-Koch-Institutes Nordufer 20 D-1000 Berlin 65 Germany Summary Pneumonia was present in 70/157 (44.6%) autopsied patients with malignant hematologic diseases. In 16/70 patients (22.9%), legionellae were found to be the causative agents by screening lung tissue specimens with the direct fluorescent antibody method. In 5/16 patients with Legionella pneumonia, in whom legionellosis had been suspected clinically, the diagnosis had already been established by serology, urinary Legionella antigen detection, and culture. These results provide evidence that legionellosis is an important pneumonia etiology in patients with malignant hematological diseases. Thus, Legionella diagnostics should be applied routinely, and antibiotics effective in the treatment of legionellosis should be added to the usual therapy in patients with etiologically unexplained pneumonias. In view of the common occurrence of relapses of Legionella pneumonia, antibiotic therapy should be continued for an extended period.

Journal

Annals of Hematology – Springer Journals

Published: Jan 1, 1988

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