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Failure to find amyloidosis in dogs treated with long-term intravenous insulin delivered by a totally implantable pump

Failure to find amyloidosis in dogs treated with long-term intravenous insulin delivered by a... 125 25 25 5 5 S. M. Mauer H. Buchwald T. J. Groppoli T. D. Rohde B. D. Wigness W. M. Rupp M. W. Steffes Department of Pediatrics University of Minnesota School of Medicine, University of Minnesota Minnesota USA Laboratory Medicine and Pathology University of Minnesota School of Medicine, University of Minnesota Minnesota USA Department of Surgery University of Minnesota School of Medicine, University of Minnesota Minnesota USA Summary We examined tissues of seven non-diabetic mongrel dogs and four diabetic beagle dogs treated with constant insulin infusion via totally implantable pumps for from 210 to 880 days. Kidney and skeletal muscle tissue from all dogs were stained with Congo Red and thioflavin-T and appropriately examined. Kidney tissues from the beagle dogs were examined by electron microscopy. No amyloid deposits were found in any of these tissues. Thus, we cannot confirm an earlier report of amyloid occurring in dogs given long-term intravenous insulin. It is concluded that amyloidosis is not a necessary complication of long-term intravenous insulin infusion in dogs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Failure to find amyloidosis in dogs treated with long-term intravenous insulin delivered by a totally implantable pump

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Springer-Verlag GmbH & Co. KG
Subject
Medicine & Public Health; Human Physiology; Internal Medicine; Metabolic Diseases
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF00282527
Publisher site
See Article on Publisher Site

Abstract

125 25 25 5 5 S. M. Mauer H. Buchwald T. J. Groppoli T. D. Rohde B. D. Wigness W. M. Rupp M. W. Steffes Department of Pediatrics University of Minnesota School of Medicine, University of Minnesota Minnesota USA Laboratory Medicine and Pathology University of Minnesota School of Medicine, University of Minnesota Minnesota USA Department of Surgery University of Minnesota School of Medicine, University of Minnesota Minnesota USA Summary We examined tissues of seven non-diabetic mongrel dogs and four diabetic beagle dogs treated with constant insulin infusion via totally implantable pumps for from 210 to 880 days. Kidney and skeletal muscle tissue from all dogs were stained with Congo Red and thioflavin-T and appropriately examined. Kidney tissues from the beagle dogs were examined by electron microscopy. No amyloid deposits were found in any of these tissues. Thus, we cannot confirm an earlier report of amyloid occurring in dogs given long-term intravenous insulin. It is concluded that amyloidosis is not a necessary complication of long-term intravenous insulin infusion in dogs.

Journal

Diabetologia – Springer Journals

Published: Nov 1, 1983

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