Curr Ophthalmol Rep (2017) 5:276–282 DOI 10.1007/s40135-017-0153-0 REGENERATIVE MEDICINE IN OPHTHALMOLOGY (D MYUNG, SECTION EDITOR) Extracellular Vesicles: Biomarkers, Therapeutics, and Vehicles in the Visual System 1,2,3 2,3,4 Yolandi van der Merwe & Michael B. Steketee Published online: 6 October 2017 Springer Science+Business Media, LLC 2017 Abstract how heterogeneous EV populations modulate positive tissue Purpose We discuss recent advances in extracellular vesicle remodeling. (EV) technology as biomarkers, therapeutics, and drug deliv- ery vehicles in the visual system with an emphasis on the . . . Keywords Extracellular vesicles Exosomes Biomarkers retina. . . . Retina Optic nerve Retinal ganglion cell miRNA Recent Findings Retinal cell-type specific EVs can be detect- ed in the blood and in the aqueous humor and EV miRNA cargoes can be used diagnostically to predict retinal disease progression. Studies have now shown EVs can deliver bioac- Introduction tive miRNA and AAV cargoes to the inner retinal cell layers and, in some models, improve retinal ganglion cell (RGC) Extracellular vesicles (EVs) are increasingly appreciated as survival and axon regeneration. important factors regulating intercellular communication in Summary EV molecular profiles and cargoes are attractive the visual system and are now being explored as biomarkers, biomarkers for retinal and
Current Ophthalmology Reports – Springer Journals
Published: Oct 6, 2017
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