213 104 104 4 4 Guy A. Higgins Brian J. Jones Nigel R. Oakley Michael B. Tyers Department of Neuropharmacology Glaxo Group Research Ltd. SG12 0DP Ware Herts UK Addiction Research Foundation 33 Russell Street M5S 2S1 Toronto Ontario Canada Smith Kline Beecham Pharmaceuticals Coldharbour Road, The Pinnacles CM19 5AD Harlow Essex UK Abstract The effects of various 5-HT 3 receptor antagonists were examined in the social interaction (SI) test following discrete microinjection into either the dorsal raphe nucleus (DRN) or amygdala of the rat. Following DRN injection, ondansetron, ICS205-930, and MDL72222 (5–500 ng) all failed to modify SI under high light/unfamiliar (HLU) test conditions relative to vehicle pretreated controls. The 5-HT 3 receptor agonist, 2-Me 5-HT (100–2500 ng), was similarly ineffective under both HLU and low light/familiar (LLF) conditions, although 5-HT (20–100 ng) increased SI under the HLU paradigm. After amygdaloid injection, ondansetron (10–100 ng), granisetron (1–10 ng), ICS205-930 (10–100 ng), GR 65630 (1–10 ng), and MDL72222 (100–1000 ng) all significantly increased SI under the HLU but not LLF condition. Furthermore, a detailed behavioural analysis revealed that the behaviours underlying this increase were similar to those seen in vehicle pretreated animals tested in the LLF compared to HLU condition. The benzodiazepine, flurazepam (200 ng), increased both SI (HLU condition) and punished responding in a modified water-lick conflict model, after amygdaloid injection. Both ondansetron (10–1000 ng) and ICS205-930 (1–100 ng) were ineffective in the conflict test. Finally, 2-Me 5-HT and 5-HT (100–10 000 ng) reduced SI under the LLF test condition with no concomitant change in locomotor activity. It is concluded that the amygdala, but not the DRN, may represent an important neuroanatomical locus for the disinhibitory, perhaps anxiolytic, properties of 5-HT 3 receptor antagonists.
Psychopharmacology – Springer Journals
Published: Aug 1, 1991
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera