Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense Test Battery

Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense... 213 106 106 4 4 D. Caroline Blanchard Jon K. Shepherd R. J. Rodgers Robert J. Blanchard Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Anatomy and Reproductive Biology, John A. Burns School of Medicine University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Psychology University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Psychology University of Leeds LS2 9JT Leeds UK Abstract The Proxemics/Activity test and the Eat/Drink test, two components of the Anxiety/Defense Test Battery, were developed to measure defensive reactions to situations associated with a natural predator (cat). In the present studies the behavioral effects of 8-OH-DPAT treatment (0.01–1.0 mg/kg, SC) were entirely consistent with anxiety/fear reduction. These effects included an increase in time spent near the cat compartment, and a complimentary decrease in time spent farthest from this compartment, together with an increase in transits and locomote behavior. 8-OH-DPAT (1.0 mg/kg) also increased eat frequencies and durations (highly preferred food) both during and following cat presentation, without influencing drinking. This finding is discussed with reference to previous findings with 8-OH-DPAT in studies assessing both food intake and anxiolysis. Interestingly, 8-OH-DPAT was more potent in a majority of its effects in female subjects, a finding consistent with recent neurochemical data. These findings provide important behavioral evidence for a sexual differentiation in 5-HT function, and support the case for greater emphasis on female subjects in animal models of anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense Test Battery

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Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02244826
Publisher site
See Article on Publisher Site

Abstract

213 106 106 4 4 D. Caroline Blanchard Jon K. Shepherd R. J. Rodgers Robert J. Blanchard Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Anatomy and Reproductive Biology, John A. Burns School of Medicine University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Psychology University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Psychology University of Leeds LS2 9JT Leeds UK Abstract The Proxemics/Activity test and the Eat/Drink test, two components of the Anxiety/Defense Test Battery, were developed to measure defensive reactions to situations associated with a natural predator (cat). In the present studies the behavioral effects of 8-OH-DPAT treatment (0.01–1.0 mg/kg, SC) were entirely consistent with anxiety/fear reduction. These effects included an increase in time spent near the cat compartment, and a complimentary decrease in time spent farthest from this compartment, together with an increase in transits and locomote behavior. 8-OH-DPAT (1.0 mg/kg) also increased eat frequencies and durations (highly preferred food) both during and following cat presentation, without influencing drinking. This finding is discussed with reference to previous findings with 8-OH-DPAT in studies assessing both food intake and anxiolysis. Interestingly, 8-OH-DPAT was more potent in a majority of its effects in female subjects, a finding consistent with recent neurochemical data. These findings provide important behavioral evidence for a sexual differentiation in 5-HT function, and support the case for greater emphasis on female subjects in animal models of anxiety.

Journal

PsychopharmacologySpringer Journals

Published: Apr 1, 1992

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