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Evaluation of the correlation of automated and manual results of complete blood count in oncologic patients

Evaluation of the correlation of automated and manual results of complete blood count in... The aim of this study is to evaluate the performance of Sysmex XS-800i analyzer and compare its correlation with standard manual method in oncologic patients. The complete blood count (CBC) with differential leukocyte count is one of the most frequently requested hematologic tests. In oncologic patients, it is more important because primary diagnosis and treatment follow-up are depending on CBC results. Automated hematology analyzers are designed to perform CBC with acceptable precision and accuracy, but manual slide examination still is needed to complement the analyzer results. One thousand CBC samples of oncologic patients analyzed by Sysmex XS-800i analyzer and the corresponding slides were examined independently by a skilled hematology technician and a pathologist. Their results analyzed for finding the degree of correlation between them. Our instrument showed excellent performance with a correlation coefficient of >0.91 for platelet and leukocyte differential count (except for basophil with r = 0.592). Sensitivity and specificity of identifying abnormal cells was 82.7 and 92 %, respectively. The Sysmex XS-800i hematology analyzer results are as reliable as the standard manual method; however, manual microscopic blood examination should be used to complete the uncompleted results, to validate analyzer flags, and for counting the cells with a flag. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Evaluation of the correlation of automated and manual results of complete blood count in oncologic patients

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References (13)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-016-2319-9
Publisher site
See Article on Publisher Site

Abstract

The aim of this study is to evaluate the performance of Sysmex XS-800i analyzer and compare its correlation with standard manual method in oncologic patients. The complete blood count (CBC) with differential leukocyte count is one of the most frequently requested hematologic tests. In oncologic patients, it is more important because primary diagnosis and treatment follow-up are depending on CBC results. Automated hematology analyzers are designed to perform CBC with acceptable precision and accuracy, but manual slide examination still is needed to complement the analyzer results. One thousand CBC samples of oncologic patients analyzed by Sysmex XS-800i analyzer and the corresponding slides were examined independently by a skilled hematology technician and a pathologist. Their results analyzed for finding the degree of correlation between them. Our instrument showed excellent performance with a correlation coefficient of >0.91 for platelet and leukocyte differential count (except for basophil with r = 0.592). Sensitivity and specificity of identifying abnormal cells was 82.7 and 92 %, respectively. The Sysmex XS-800i hematology analyzer results are as reliable as the standard manual method; however, manual microscopic blood examination should be used to complete the uncompleted results, to validate analyzer flags, and for counting the cells with a flag.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Aug 13, 2016

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