Epinephrine/perindopril

Epinephrine/perindopril Reactions 1680, p126 - 2 Dec 2017 Angioedema and myocardial infarction: case report A 46-year-old woman developed angioedema during treatment with perindopril and type 2 myocardial infarction after wrongful administration of epinephrine [adrenaline; not all route and time to reaction onset stated]. The woman with obesity, smoking habits and hypertension, received perindopril 10 mg/day for about one year. She presented to emergency department with swelling in the arms, hands and face. She also complained of dyspnoea. She was suspected to have anaphylaxis instead of being diagnosed as perindopril induced angioedema, which was later revealed after discontinuation of perindopril. The woman was treated with hydrocortisone, clemastine and IV epinephrine 1mg for suspected anaphylaxis. However, she developed nausea, chest pain, hypotension with arterial pressure 60/27 mmHg, sinus tachycardia (150 bpm) and tachypnea 27 cycles/minute. ECG revealed ST-segment elevation with reciprocal ST-segment depression and hypokinesis of lateral and medio-basal inferior walls. She was treated with nitroglycerin [nytroglicerine], which was repeated after 5 minutes. Partial improvement in pain and decrease in elevated ST-segment was noted. Intravascular ultrasound (IVUS) showed 78% stenosis, and coronary angiography exhibited an intermediate lesion in the distal right coronary, which was treated with a drug eluting stent. Blood analysis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Epinephrine/perindopril

Reactions Weekly, Volume 1680 (1) – Dec 2, 2017

Epinephrine/perindopril

Abstract

Reactions 1680, p126 - 2 Dec 2017 Angioedema and myocardial infarction: case report A 46-year-old woman developed angioedema during treatment with perindopril and type 2 myocardial infarction after wrongful administration of epinephrine [adrenaline; not all route and time to reaction onset stated]. The woman with obesity, smoking habits and hypertension, received perindopril 10 mg/day for about one year. She presented to emergency department with swelling in the arms, hands and face. She also...
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-39057-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p126 - 2 Dec 2017 Angioedema and myocardial infarction: case report A 46-year-old woman developed angioedema during treatment with perindopril and type 2 myocardial infarction after wrongful administration of epinephrine [adrenaline; not all route and time to reaction onset stated]. The woman with obesity, smoking habits and hypertension, received perindopril 10 mg/day for about one year. She presented to emergency department with swelling in the arms, hands and face. She also complained of dyspnoea. She was suspected to have anaphylaxis instead of being diagnosed as perindopril induced angioedema, which was later revealed after discontinuation of perindopril. The woman was treated with hydrocortisone, clemastine and IV epinephrine 1mg for suspected anaphylaxis. However, she developed nausea, chest pain, hypotension with arterial pressure 60/27 mmHg, sinus tachycardia (150 bpm) and tachypnea 27 cycles/minute. ECG revealed ST-segment elevation with reciprocal ST-segment depression and hypokinesis of lateral and medio-basal inferior walls. She was treated with nitroglycerin [nytroglicerine], which was repeated after 5 minutes. Partial improvement in pain and decrease in elevated ST-segment was noted. Intravascular ultrasound (IVUS) showed 78% stenosis, and coronary angiography exhibited an intermediate lesion in the distal right coronary, which was treated with a drug eluting stent. Blood analysis

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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