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- Publisher
- Springer Journals
- Copyright
- Copyright © 1998 by Plenum Publishing Corporation
- Subject
- Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
- ISSN
- 0724-8741
- eISSN
- 1573-904X
- DOI
- 10.1023/A:1011907201096
- Publisher site
- See Article on Publisher Site
Abstract
Purpose. An integrated ionic mobility-pore model for epidermal iontophoresis is developed from theoretical considerations using both the free volume and pore restriction forms of the model for a range of solute radii (r j ) approaching the pore radii (r p ) as well as approximation of the pore restriction form for r j /r p < 0.4. In this model, we defined the determinants for iontophoresis as solute size (defined by MV, MW or radius), solute mobility, solute shape, solute charge, the Debye layer thickness, total current applied, solute concentration, fraction ionized, presence of extraneous ions (defined by solvent conductivity), epidermal permselectivity, partitioning rates to account for interaction of unionized and ionized lipophilic solutes with the wall of the pore and electroosmosis.
Journal
Pharmaceutical Research – Springer Journals
Published: Oct 8, 2004