Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Epidemiology, Pathological Characteristics and Estrogen and Progesterone Receptor Status of Operated Cases of Female Breast Cancer: A Retrospective Review of 266 Cases from Kerala

Epidemiology, Pathological Characteristics and Estrogen and Progesterone Receptor Status of... Abstract Breast cancer is presently the most common cancer among women in Kerala, in Southern India. The objectives of this study were to analyze the epidemiology and pathological characteristics of female breast carcinoma in Kerala. 266 patients who were diagnosed with operable breast cancer between April 2009 and June 2010 were studied. Various pathological characteristics including stage, grade, axillary lymph nodal status, tumor size, and estrogen and progesterone receptor status were studied. Estrogen and progesterone receptor status were evaluated by immunohistochemistry. Chi-square test and frequency tables were used for statistical analysis. The mean age at presentation was 50 years. 48.9 % of the patients were premenopausal. 53.76 % had grade II tumors. Positive axillary lymph nodes were found in 70.3 % patients, and 68 % presented with stage II disease. 54.13 % were ER positive and 62 % were PR positive. The relatively young age at diagnosis, late presentation of the disease, and lower estrogen and progesterone receptor expression compared to patients from the West point toward the need for better breast cancer awareness and screening programmes in Kerala. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Surgical Oncology Springer Journals

Epidemiology, Pathological Characteristics and Estrogen and Progesterone Receptor Status of Operated Cases of Female Breast Cancer: A Retrospective Review of 266 Cases from Kerala

Download PDF
4 pages

Loading next page...
 
/lp/springer-journals/epidemiology-pathological-characteristics-and-estrogen-and-NS7hdl3tTp
Publisher
Springer Journals
Copyright
2015 Indian Association of Surgical Oncology
ISSN
0975-7651
eISSN
0976-6952
DOI
10.1007/s13193-015-0425-9
Publisher site
See Article on Publisher Site

Abstract

Abstract Breast cancer is presently the most common cancer among women in Kerala, in Southern India. The objectives of this study were to analyze the epidemiology and pathological characteristics of female breast carcinoma in Kerala. 266 patients who were diagnosed with operable breast cancer between April 2009 and June 2010 were studied. Various pathological characteristics including stage, grade, axillary lymph nodal status, tumor size, and estrogen and progesterone receptor status were studied. Estrogen and progesterone receptor status were evaluated by immunohistochemistry. Chi-square test and frequency tables were used for statistical analysis. The mean age at presentation was 50 years. 48.9 % of the patients were premenopausal. 53.76 % had grade II tumors. Positive axillary lymph nodes were found in 70.3 % patients, and 68 % presented with stage II disease. 54.13 % were ER positive and 62 % were PR positive. The relatively young age at diagnosis, late presentation of the disease, and lower estrogen and progesterone receptor expression compared to patients from the West point toward the need for better breast cancer awareness and screening programmes in Kerala.

Journal

Indian Journal of Surgical Oncology – Springer Journals

Published: Dec 1, 2015

Keywords: surgical oncology; oncology; surgery

References

  • Consolidated report of the population based cancer registries.1990–1996.Indian Council of Medical Research;2001
    National Cancer Registry Programme
  • ASCO-CAP guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
    MEH Hammond, DF Hayes, M Dowsett, DC Allred, KL Hagerty, S Badve, PL Fitzgibbons, G Francis, NS Goldstein, M Hayes, DG Hicks, S Lester, R Love, PB Mangu, L McShane, K Miller, CK Osborne, S Paik, J Perlmutter, A Rhodes, H Sasano, JN Schawrtz, FCG Sweep, S Taube, EE Torlakovic, P Valenstein, G Viale, D Visscher, RB Wheeler Williams
  • //seer.cancer.gov/statfacts/html/breast.html]
    SEER-Stat database [http
  • Is breast cancer the same disease in Asian and western countries?
    SPL Leong, ZZ Shen, TJ Liu, G Agarwal, T Tajima, N Paik
  • Survival pattern among younger women with breast cancer:the effects of age,race,stage and treatment
    GM Swanson, CS Lin
  • Effects of young age at presentation on survival in breast cancer
    NS Saghir, M Seoud, MK Khalil
  • Patterns of breast cancer presentation in the United States: does geography matter?
    J Sariego
  • Triple negative breast cancer are increased in black women regardless of age or BMI
    LA Stead, TL Lash, JE Sobieraj
  • Do we need Her2/neu testing for all patients with primary breast carcinoma?
    S Taucher, M Rudas, RM Mader
  • Clinico-morphological pattern of breast cancer including family history in a New Delhi hospital,India-a cross sectional study
    S Saxena, B Rekhi, A Bansal
  • Erb B-2 expression and its association with other biological parameters of breast cancer among Indian women
    K Vaidyanathan, P Kumar, CO Reddy
  • Frequency of estrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening
    A Rhodes, B Jasani, AJ Balaton, DM Barnes, KD Miller
  • Hormone receptor status of breast cancer in the Himalayan region of Northern India
    Rashmi K, Jaishree S, Satinder SM, Kavita M
  • Risk factors according to estrogen receptor status of breast cancer patients in Trivandrum,South India
    S Dey, P Bofetta, A Mathews, P Brennan, A Soliman
  • Breast cancer in young women: poor survival despite intensive treatment
    H Fredholm, S Eaker, J Frissel, L Homberg, I Fredrickson, H Lindman