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Uterine sarcomas comprise 2–3% of all uterine malignancies. Tumors in this category are, in order of decreasing incidence, carcinosarcoma, leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. Endometrial stromal sarcomas are divided into low- and high-grade according to tumor cell morphology and mitotic rate. Low-grade tumors are characterized by a slow growth pattern, presence of estrogen and/or progesterone receptors, and an indolent clinical course with late recurrences. Despite this indolent course, 37–60% of patients with early-stage disease experience recurrent disease. High-grade stromal sarcomas, on the other hand, exhibit more aggressive biological behavior and poor outcome.
American Journal of Cancer – Springer Journals
Published: Aug 10, 2012
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