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Electrophysiological comparison of the action of imipramine and propazepine

Electrophysiological comparison of the action of imipramine and propazepine 213 3 3 6 6 O. Benešová Z. Bohdanecký Z. Votava Department of Pharmacology Medical College of Hygiene and Research Institute for Pharmacy and Biochemistry Prague CSSR Summary Imipramine and its structural isomer propazepine were compared using 3 electrophysiological methods with these results: 1. EEG records in cortical and subcortical areas (hippocampus, thalamus) in rabbits with implanted electrodes after the administration of both drugs (5 mg/kg i.v.) did not differ. Imipramine had a greater antagonistic effect to cortical desynchronisation and subcortical synchronisation evoked by physostigmine (0,1 mg/kg i.V.). 2. The potentiation of thiopental anaesthesia measured by motor thresholds in rabbits with permanent epidural electrodes was greater after the administration of propazepine (2,5 mg/kg i.V.). 3. Imipramine (1 mg/kg, 1,5 mg/kg, 2 mg/kg i.p.) decreased the rate of self-stimulation in rats with electrodes implanted in ventrolateral hypothalamus, whilst propazepine in the dose of 1,5 mg/kg i.p. caused a significant increase in the rate of self-stimulation on the second day and in the dose of 2 mg/kg i.p. a significant decrease on the first day after the administration. The results are discussed in respect to the clinical use. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Electrophysiological comparison of the action of imipramine and propazepine

Psychopharmacology , Volume 3 (6) – Nov 1, 1962

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 1962 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00411159
Publisher site
See Article on Publisher Site

Abstract

213 3 3 6 6 O. Benešová Z. Bohdanecký Z. Votava Department of Pharmacology Medical College of Hygiene and Research Institute for Pharmacy and Biochemistry Prague CSSR Summary Imipramine and its structural isomer propazepine were compared using 3 electrophysiological methods with these results: 1. EEG records in cortical and subcortical areas (hippocampus, thalamus) in rabbits with implanted electrodes after the administration of both drugs (5 mg/kg i.v.) did not differ. Imipramine had a greater antagonistic effect to cortical desynchronisation and subcortical synchronisation evoked by physostigmine (0,1 mg/kg i.V.). 2. The potentiation of thiopental anaesthesia measured by motor thresholds in rabbits with permanent epidural electrodes was greater after the administration of propazepine (2,5 mg/kg i.V.). 3. Imipramine (1 mg/kg, 1,5 mg/kg, 2 mg/kg i.p.) decreased the rate of self-stimulation in rats with electrodes implanted in ventrolateral hypothalamus, whilst propazepine in the dose of 1,5 mg/kg i.p. caused a significant increase in the rate of self-stimulation on the second day and in the dose of 2 mg/kg i.p. a significant decrease on the first day after the administration. The results are discussed in respect to the clinical use.

Journal

PsychopharmacologySpringer Journals

Published: Nov 1, 1962

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