Electrophysiological and anatomical observations concerning the pallidostriatal pathway in the rat

Electrophysiological and anatomical observations concerning the pallidostriatal pathway in the rat 221 74 74 2 2 R. H. Walker G. W. Arbuthnott A. K. Wright MRC Brain Metabolism Unit University Department of Pharmacology 1 George Square EH8 9JZ Edinburgh UK Summary Anatomical studies in several species have demonstrated a pallidostriatal pathway. We employed electrophysiological and anatomical methods to distinguish the neurones of this pathway from the two pallidocortical groups reported in the rat. Injection of fluorescent retrograde tracers, combined with immunohistochemistry for choline acetyltransferase, provided anatomical evidence of the distinction between neurones of the cholinergic pallidocortical projection and pallidal cells retrogradely labelled from the striatum. Extracellular recordings made in the globus pallidus of halothane-anaesthetised rats provided an electrophysiological description of the pallidostriatal pathway. In some animals neurones of this pathway were distinguished from pallidocortical neurones as a stimulating electrode, situated in the crus cerebri, permitted identification of neurones which projected through this region as well as to the striatum. Neither pallidocortical pathway is reported to have descending axons travelling in the crus cerebri at this point. A preliminary electrophysiological study was carried out in rats in which the dopamine-containing cells of substantia nigra had been destroyed by injections of 6-hydroxydopamine at least 6 months prior to the recording. In the globus pallidus on the lesioned side the mean firing rate of neurones was increased compared with controls. No specific change in firing pattern was noted but the neurones were more responsive to striatal stimulation suggesting that long-term dopamine denervation alters the sensitivity of neurones of globus pallidus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Electrophysiological and anatomical observations concerning the pallidostriatal pathway in the rat

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Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
D.O.I.
10.1007/BF00248863
Publisher site
See Article on Publisher Site

Abstract

221 74 74 2 2 R. H. Walker G. W. Arbuthnott A. K. Wright MRC Brain Metabolism Unit University Department of Pharmacology 1 George Square EH8 9JZ Edinburgh UK Summary Anatomical studies in several species have demonstrated a pallidostriatal pathway. We employed electrophysiological and anatomical methods to distinguish the neurones of this pathway from the two pallidocortical groups reported in the rat. Injection of fluorescent retrograde tracers, combined with immunohistochemistry for choline acetyltransferase, provided anatomical evidence of the distinction between neurones of the cholinergic pallidocortical projection and pallidal cells retrogradely labelled from the striatum. Extracellular recordings made in the globus pallidus of halothane-anaesthetised rats provided an electrophysiological description of the pallidostriatal pathway. In some animals neurones of this pathway were distinguished from pallidocortical neurones as a stimulating electrode, situated in the crus cerebri, permitted identification of neurones which projected through this region as well as to the striatum. Neither pallidocortical pathway is reported to have descending axons travelling in the crus cerebri at this point. A preliminary electrophysiological study was carried out in rats in which the dopamine-containing cells of substantia nigra had been destroyed by injections of 6-hydroxydopamine at least 6 months prior to the recording. In the globus pallidus on the lesioned side the mean firing rate of neurones was increased compared with controls. No specific change in firing pattern was noted but the neurones were more responsive to striatal stimulation suggesting that long-term dopamine denervation alters the sensitivity of neurones of globus pallidus.

Journal

Experimental Brain ResearchSpringer Journals

Published: Jan 1, 1989

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