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Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects

Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks... 213 14 14 3 3 Ann Malpas C. R. B. Joyce Department of Pharmacology and Therapeutics The London Hospital Medical College Great Britain Summary Some behavioural effects of placebo, 5 and 10 mg of nitrazepam and 100 and 200 mg of sodium amylobarbitone were compared in 10 healthy young subjects. Both doses of nitrazepam had a more pronounced effect upon measures of motor response time, decision time and digit symbol substitution than either dose of the barbiturate, but the effects of the benzodiazepine were probably diminishing at a time (150 min after drug administration) when those of the barbiturate were still increasing. Nitrazepam markedly increased the latency of after-image development and reduced its duration. There was a tendency for an increased information load to slow decision time more when subjects were treated with sodium amylobarbitone than with nitrazepam. Comparison of performance under placebo of subjects who did and did not sleep when treated with 10 mg nitrazepam suggested that the effects of this dose of the drug were predominantly hypnotic for the former and “tranquillizing” for the latter. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects

Psychopharmacology , Volume 14 (3) – Jan 1, 1969

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References (23)

Publisher
Springer Journals
Copyright
Copyright © 1969 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00404214
Publisher site
See Article on Publisher Site

Abstract

213 14 14 3 3 Ann Malpas C. R. B. Joyce Department of Pharmacology and Therapeutics The London Hospital Medical College Great Britain Summary Some behavioural effects of placebo, 5 and 10 mg of nitrazepam and 100 and 200 mg of sodium amylobarbitone were compared in 10 healthy young subjects. Both doses of nitrazepam had a more pronounced effect upon measures of motor response time, decision time and digit symbol substitution than either dose of the barbiturate, but the effects of the benzodiazepine were probably diminishing at a time (150 min after drug administration) when those of the barbiturate were still increasing. Nitrazepam markedly increased the latency of after-image development and reduced its duration. There was a tendency for an increased information load to slow decision time more when subjects were treated with sodium amylobarbitone than with nitrazepam. Comparison of performance under placebo of subjects who did and did not sleep when treated with 10 mg nitrazepam suggested that the effects of this dose of the drug were predominantly hypnotic for the former and “tranquillizing” for the latter.

Journal

PsychopharmacologySpringer Journals

Published: Jan 1, 1969

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