Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Monaghan, C. Cotman (1985)
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain, 5
R. Morris (1981)
Spatial Localization Does Not Require the Presence of Local CuesLearning and Motivation, 12
M. Upchurch, J. Wehner (1987)
Effects of chronic diisopropylfluorophosphate treatment on spatial learning in micePharmacology Biochemistry and Behavior, 27
I. Whishaw, W. O’Connor, S. Dunnett (1985)
Disruption of central cholinergic systems in the rat by basal forebrain lesions or atropine: Effects on feeding, sensorimotor behaviour, locomotor activity and spatial navigationBehavioural Brain Research, 17
J. Sinha, Shreya Agarwal, Shampa Ghosh (2019)
Long-Term PotentiationEncyclopedia of Animal Cognition and Behavior
I. Whishaw, G. Mittleman (1986)
Visits to starts, routes, and places by rats (Rattus norvegicus) in swimming pool navigation tasks.Journal of comparative psychology, 100 4
C. Boast, G. Pastor (1987)
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbilsPharmacology Biochemistry and Behavior, 27
I. Whishaw (1985)
Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool.Behavioral neuroscience, 99 5
Robert Sutherland, I. Whishaw, Bryan Kolb (1983)
A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the ratBehavioural Brain Research, 7
R. Morris, P. Garrud, J. Rawlins, J. O’Keefe (1982)
Place navigation impaired in rats with hippocampal lesionsNature, 297
J. Lehmann, J. Schneider, S. McPherson, D. Murphy, P. Bernard, C. Tsai, D. Bennett, G. Pastor, D. Steel, C. Boehm (1987)
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.The Journal of pharmacology and experimental therapeutics, 240 3
B. Kolb, R. Sutherland, I. Whishaw (1983)
A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.Behavioral neuroscience, 97 1
M. Upchurch, J. Wehner (1988)
Differences between inbred strains of mice in Morris water maze performanceBehavior Genetics, 18
K. O'Neill, J. Liebman (1987)
Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of ratsBrain Research, 435
R. Morris, Elizabeth Anderson, G. Lynch, M. Baudry (1986)
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Nature, 319
213 100 100 2 2 Margaret Upchurch Jeanne M. Wehner Institute for Behavioral Genetics University of Colorado Campus Box 447 80309 Boulder CO USA Department of Psychology, Benedictine College 66002 Atchison KS USA Abstract C57BL/6Ibg mice were treated with the N-methyl- d -aspartate (NMDA) receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) and tested for selective deficits in spatial learning ability in the Morris water task. Two types of training protocols were used during the initial exposure to the training environment. In protocol 1, animals were given four massed trials before being returned to their home cages. In protocol 2, animals were returned to their home cages after each of the first four trials. Following the initial four trials, both sets of animals were given massed trials in blocks of four. CPP had minor effects on nonspatial learning, with greater impairment seen in animals trained according to protocol 1 than in animals trained according to protocol 2. The drug increased latency to find the platform in the spatial learning form of the task, with no effect of training protocol on latency. When spatial learning ability was measured in terms of the search behavior exhibited by the animals after the platform was removed from the pool, animals trained according to protocol 1 showed a severe CPP-induced impairment in search accuracy. Animals trained according to protocol 2 showed no effect of drug treatment. The results suggest that CPP does not have a reliable effect on place learning and that factors other than the type of learning being tested may contribute to performance deficits following CPP treatment.
Psychopharmacology – Springer Journals
Published: Feb 1, 1990
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.