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Effects of N-methyl- d -aspartate antagonism on spatial learning in mice

Effects of N-methyl- d -aspartate antagonism on spatial learning in mice 213 100 100 2 2 Margaret Upchurch Jeanne M. Wehner Institute for Behavioral Genetics University of Colorado Campus Box 447 80309 Boulder CO USA Department of Psychology, Benedictine College 66002 Atchison KS USA Abstract C57BL/6Ibg mice were treated with the N-methyl- d -aspartate (NMDA) receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) and tested for selective deficits in spatial learning ability in the Morris water task. Two types of training protocols were used during the initial exposure to the training environment. In protocol 1, animals were given four massed trials before being returned to their home cages. In protocol 2, animals were returned to their home cages after each of the first four trials. Following the initial four trials, both sets of animals were given massed trials in blocks of four. CPP had minor effects on nonspatial learning, with greater impairment seen in animals trained according to protocol 1 than in animals trained according to protocol 2. The drug increased latency to find the platform in the spatial learning form of the task, with no effect of training protocol on latency. When spatial learning ability was measured in terms of the search behavior exhibited by the animals after the platform was removed from the pool, animals trained according to protocol 1 showed a severe CPP-induced impairment in search accuracy. Animals trained according to protocol 2 showed no effect of drug treatment. The results suggest that CPP does not have a reliable effect on place learning and that factors other than the type of learning being tested may contribute to performance deficits following CPP treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effects of N-methyl- d -aspartate antagonism on spatial learning in mice

Upchurch, Margaret; Wehner, Jeanne
Psychopharmacology , Volume 100 (2) – Feb 1, 1990
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References (15)

Publisher
Springer Journals
Copyright
Copyright © 1990 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02244408
Publisher site
See Article on Publisher Site

Abstract

213 100 100 2 2 Margaret Upchurch Jeanne M. Wehner Institute for Behavioral Genetics University of Colorado Campus Box 447 80309 Boulder CO USA Department of Psychology, Benedictine College 66002 Atchison KS USA Abstract C57BL/6Ibg mice were treated with the N-methyl- d -aspartate (NMDA) receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) and tested for selective deficits in spatial learning ability in the Morris water task. Two types of training protocols were used during the initial exposure to the training environment. In protocol 1, animals were given four massed trials before being returned to their home cages. In protocol 2, animals were returned to their home cages after each of the first four trials. Following the initial four trials, both sets of animals were given massed trials in blocks of four. CPP had minor effects on nonspatial learning, with greater impairment seen in animals trained according to protocol 1 than in animals trained according to protocol 2. The drug increased latency to find the platform in the spatial learning form of the task, with no effect of training protocol on latency. When spatial learning ability was measured in terms of the search behavior exhibited by the animals after the platform was removed from the pool, animals trained according to protocol 1 showed a severe CPP-induced impairment in search accuracy. Animals trained according to protocol 2 showed no effect of drug treatment. The results suggest that CPP does not have a reliable effect on place learning and that factors other than the type of learning being tested may contribute to performance deficits following CPP treatment.

Journal

Psychopharmacology – Springer Journals

Published: Feb 1, 1990

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