213 88 88 4 4 R. Nemeth-Coslett Jack E. Henningfield Mary K. O'Keeffe Roland R. Griffiths Department of Psychiatry The Johns Hopkins University School of Medicine Baltimore MD USA Department of Neuroscience The Johns Hopkins University School of Medicine Baltimore MD USA National Institute on Drug Abuse Addiction Research Center Baltimore MD USA Psychiatry, 623 Traylor The Johns Hopkins University School of Medicine 21205 Baltimore MD USA Abstract Multiple measures of cigarette smoking, subjective effect and physiological effect were collected during 90-min test sessions in normal volunteers. Before sessions subjects received oral doses of mecamylamine (2.5, 5.0, 10, 20 mg) or placebo. Each dose and placebo was given three times in a randomized block sequence. Mecamylamine increased several measures of cigarette smoking, including number of cigarettes, number of puffs per cigarette, and expired air carbon monoxide level. Mecamylamine also produced modest, dose-related decreases in standing blood pressure and increases in standing heart rate. The subjective effects produced by mecamylamine were not characteristic of those of psychoactive drugs. Mecamylamine appears to have increased cigarette smoking by decreasing the effective dose level of nicotine available from cigarette smoking.
Psychopharmacology – Springer Journals
Published: Apr 1, 1986
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