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Effects of clonidine and some α-adrenoreceptor blocking agents on avoidance conditioned reflexes in rats: Their interactions and antagonism by atropine

Effects of clonidine and some α-adrenoreceptor blocking agents on avoidance conditioned reflexes... 213 35 35 3 3 Bernard Delbarre Henri Schmitt Faculté des Sciences Laboratoire de Neurophysiologie Poitiers Faculté de Médecine, Broussais HÔtel-Dieu 75006 Paris Abstract Clonidine (150 Μg/kg s. c.) depressed avoidance conditioned reflexes in Long-Evans rats. Some α -adrenoceptor blocking agents piperoxan, tolazoline, phentolamine, dibenamine and phenoxybenzamine also depressed these reflexes. Yohimbine (1–2 mg/kg) was found to have no significant effect. Atropine (10 to 15 mg/kg i. p.) antagonized the depression of conditioned avoidance reflexes induced by α -adrenoceptor blocking agents as well as the depression produced by clonidine. Yohimbine (1–2 mg/kg) reduced the depressing effects of clonidine on avoidance conditioned reflexes. In rats treated with piperoxan (10 mg/kg) the effects of clonidine were reduced. In these rats the depression of conditioned reflexes was less than in rats treated with clonidine or piperoxan alone. These experiments suggest that clonidine depressed avoidance conditioned reflexes in rats by activating central α -adrenoceptors. It is proposed that α -adrenoceptor blocking agents might act as partial agonists. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effects of clonidine and some α-adrenoreceptor blocking agents on avoidance conditioned reflexes in rats: Their interactions and antagonism by atropine

Psychopharmacology , Volume 35 (3) – Sep 1, 1974

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References (26)

Publisher
Springer Journals
Copyright
Copyright © 1974 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00437748
Publisher site
See Article on Publisher Site

Abstract

213 35 35 3 3 Bernard Delbarre Henri Schmitt Faculté des Sciences Laboratoire de Neurophysiologie Poitiers Faculté de Médecine, Broussais HÔtel-Dieu 75006 Paris Abstract Clonidine (150 Μg/kg s. c.) depressed avoidance conditioned reflexes in Long-Evans rats. Some α -adrenoceptor blocking agents piperoxan, tolazoline, phentolamine, dibenamine and phenoxybenzamine also depressed these reflexes. Yohimbine (1–2 mg/kg) was found to have no significant effect. Atropine (10 to 15 mg/kg i. p.) antagonized the depression of conditioned avoidance reflexes induced by α -adrenoceptor blocking agents as well as the depression produced by clonidine. Yohimbine (1–2 mg/kg) reduced the depressing effects of clonidine on avoidance conditioned reflexes. In rats treated with piperoxan (10 mg/kg) the effects of clonidine were reduced. In these rats the depression of conditioned reflexes was less than in rats treated with clonidine or piperoxan alone. These experiments suggest that clonidine depressed avoidance conditioned reflexes in rats by activating central α -adrenoceptors. It is proposed that α -adrenoceptor blocking agents might act as partial agonists.

Journal

PsychopharmacologySpringer Journals

Published: Sep 1, 1974

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