Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of Bioactive Factors of the Pineal Gland on Thymus Function and Cell Composition of the Bone Marrow and Spleen in Mice of Different Age

Effects of Bioactive Factors of the Pineal Gland on Thymus Function and Cell Composition of the... The effects of factors from the pineal gland on the titer of thymic serum factor in the supernatant of 3-h thymus stroma cultures, number of stromal precursor fibroblasts and CD4+ cells in the bone marrow, and CD8+ cells in the spleens of adult and old CBA mice were studied in vitro. Epithalamin, Epithalon, and melatonin appreciably increased the titer of thymic serum factor in the supernatant of thymus stroma cultures from mice of different age and increased the percentage of CD4+ cells in the bone marrow suspension from old animals in vitro. The percentage of CD8+ lymphocytes decreased after incubation of splenic cells from old mice with melatonin. The percentage of bone marrow fibroblast precursor cells from adult and old mice did not appreciably change after incubation with the preparations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bulletin of Experimental Biology and Medicine Springer Journals

Effects of Bioactive Factors of the Pineal Gland on Thymus Function and Cell Composition of the Bone Marrow and Spleen in Mice of Different Age

Loading next page...
 
/lp/springer-journals/effects-of-bioactive-factors-of-the-pineal-gland-on-thymus-function-NLAtawXdtY

References (5)

Publisher
Springer Journals
Copyright
Copyright © 2004 by Plenum Publishing Corporation
Subject
Biomedicine; Biomedicine, general; Internal Medicine; Cell Biology; Pathology; Laboratory Medicine
ISSN
0007-4888
eISSN
1573-8221
DOI
10.1023/B:BEBM.0000038166.54823.06
Publisher site
See Article on Publisher Site

Abstract

The effects of factors from the pineal gland on the titer of thymic serum factor in the supernatant of 3-h thymus stroma cultures, number of stromal precursor fibroblasts and CD4+ cells in the bone marrow, and CD8+ cells in the spleens of adult and old CBA mice were studied in vitro. Epithalamin, Epithalon, and melatonin appreciably increased the titer of thymic serum factor in the supernatant of thymus stroma cultures from mice of different age and increased the percentage of CD4+ cells in the bone marrow suspension from old animals in vitro. The percentage of CD8+ lymphocytes decreased after incubation of splenic cells from old mice with melatonin. The percentage of bone marrow fibroblast precursor cells from adult and old mice did not appreciably change after incubation with the preparations.

Journal

Bulletin of Experimental Biology and MedicineSpringer Journals

Published: Sep 24, 2004

There are no references for this article.