Effect of SB 200646A, a 5-HT 2C /5-HT 2B receptor antagonist, in two conflict models of anxiety

Effect of SB 200646A, a 5-HT 2C /5-HT 2B receptor antagonist, in two conflict models of anxiety 213 118 118 2 2 G. A. Kennett F. Bailey D. C. Piper T. P. Blackburn SmithKline Beecham Coldharbour Road, The Pinnacles CM19 5AD Harlow Essex UK Abstract SB 200646A is the first selective 5-HT 2C /5-HT 2B receptor antagonist and has previously been observed to have anxiolytic-like properties in the rat social interaction test. In the present study the effects of the compound in two conflict models of anxiety, the rat Geller-Seifter and marmoset conflict test, were examined. In the rat Geller-Seifter test, suppressed responding was increased by all doses of SB 200646A between 5 and 40 mg/kg PO when given 1 h pretest. Unsuppressed responding was slightly increased only at 10 mg/kg PO. Suppressed responding was also increased by the benzodiazepine anxiolytic, chlordiazepoxide, at 1, 2.5 and 5 mg/kg PO 1 h pretest. Unsuppressed responding was modestly increased by chlordiazepoxide only at 5 mg/kg PO. In the marmoset conflict test marmosets were trained to lever press for a palatable food reward. Lever pressing was subsequently suppressed by air puffs. In this procedure suppressed responding was increased by both the benzodiazepine anxiolytic diazepam at 2 and 5 mg/kg PO and SB 200646A after 10 and 20 mg/kg PO. Both treatments caused small increases in unsuppressed responding at 2 and 20 mg/kg PO respectively. Taken together with the previous effects of SB 200646A in the rat social interaction test, this is compelling evidence that 5-HT 2C/2B receptor antagonists may possess anxiolytic properties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effect of SB 200646A, a 5-HT 2C /5-HT 2B receptor antagonist, in two conflict models of anxiety

Psychopharmacology, Volume 118 (2) – Mar 1, 1995

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Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245837
Publisher site
See Article on Publisher Site

Abstract

213 118 118 2 2 G. A. Kennett F. Bailey D. C. Piper T. P. Blackburn SmithKline Beecham Coldharbour Road, The Pinnacles CM19 5AD Harlow Essex UK Abstract SB 200646A is the first selective 5-HT 2C /5-HT 2B receptor antagonist and has previously been observed to have anxiolytic-like properties in the rat social interaction test. In the present study the effects of the compound in two conflict models of anxiety, the rat Geller-Seifter and marmoset conflict test, were examined. In the rat Geller-Seifter test, suppressed responding was increased by all doses of SB 200646A between 5 and 40 mg/kg PO when given 1 h pretest. Unsuppressed responding was slightly increased only at 10 mg/kg PO. Suppressed responding was also increased by the benzodiazepine anxiolytic, chlordiazepoxide, at 1, 2.5 and 5 mg/kg PO 1 h pretest. Unsuppressed responding was modestly increased by chlordiazepoxide only at 5 mg/kg PO. In the marmoset conflict test marmosets were trained to lever press for a palatable food reward. Lever pressing was subsequently suppressed by air puffs. In this procedure suppressed responding was increased by both the benzodiazepine anxiolytic diazepam at 2 and 5 mg/kg PO and SB 200646A after 10 and 20 mg/kg PO. Both treatments caused small increases in unsuppressed responding at 2 and 20 mg/kg PO respectively. Taken together with the previous effects of SB 200646A in the rat social interaction test, this is compelling evidence that 5-HT 2C/2B receptor antagonists may possess anxiolytic properties.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1995

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