Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effect of Nano-zirconia on Microstructure and Biological Behavior of Hydroxyapatite-Based Bone Scaffolds

Effect of Nano-zirconia on Microstructure and Biological Behavior of Hydroxyapatite-Based Bone... In this research study, the effect of zirconia nanoparticles on the biological properties of the hydroxyapatite (HA) scaffolds was evaluated. The zirconia nanoparticles with various weight percentages of 5, 10, and 20 were mixed with hydroxyapatite powder using a ball-milling process. Then, they were cold pressed and heat-treated at 1150 °C. Scanning electron microscope and x-ray diffraction analysis were used to evaluate the morphology and phase analysis of the samples, respectively. The results of the microstructure and phase analysis revealed that some zirconia nanoparticles reacted with the HA during the sintering process, which besides the formation of the tertiary calcium phosphate and calcium zirconium phases, it resulted in creating some microporosities in the scaffold. The biological behavior of the samples was investigated by osteoblast-like cells. The results of the biological assessment demonstrated that the presence of the zirconia nanoparticles in the HA scaffold improved the biological behavior (cell attachment and cell proliferation). The HA specimen composed with 10 wt.% zirconia nanoparticles showed the highest bioactivity. In addition, the compressive strength of the HA sample composed of 10 wt.% zirconia nanoparticles was improved by 30%. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Engineering and Performance Springer Journals

Effect of Nano-zirconia on Microstructure and Biological Behavior of Hydroxyapatite-Based Bone Scaffolds

Loading next page...
 
/lp/springer-journals/effect-of-nano-zirconia-on-microstructure-and-biological-behavior-of-J7kvxC0Xkz

References (47)

Publisher
Springer Journals
Copyright
Copyright © ASM International 2020
ISSN
1059-9495
eISSN
1544-1024
DOI
10.1007/s11665-020-04927-2
Publisher site
See Article on Publisher Site

Abstract

In this research study, the effect of zirconia nanoparticles on the biological properties of the hydroxyapatite (HA) scaffolds was evaluated. The zirconia nanoparticles with various weight percentages of 5, 10, and 20 were mixed with hydroxyapatite powder using a ball-milling process. Then, they were cold pressed and heat-treated at 1150 °C. Scanning electron microscope and x-ray diffraction analysis were used to evaluate the morphology and phase analysis of the samples, respectively. The results of the microstructure and phase analysis revealed that some zirconia nanoparticles reacted with the HA during the sintering process, which besides the formation of the tertiary calcium phosphate and calcium zirconium phases, it resulted in creating some microporosities in the scaffold. The biological behavior of the samples was investigated by osteoblast-like cells. The results of the biological assessment demonstrated that the presence of the zirconia nanoparticles in the HA scaffold improved the biological behavior (cell attachment and cell proliferation). The HA specimen composed with 10 wt.% zirconia nanoparticles showed the highest bioactivity. In addition, the compressive strength of the HA sample composed of 10 wt.% zirconia nanoparticles was improved by 30%.

Journal

Journal of Materials Engineering and PerformanceSpringer Journals

Published: Jul 6, 2020

There are no references for this article.