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Effect of l -lysine-α-oxidase on the synthesis of proteins associated with autoimmune pathologies in HIV infection



In HIV-infected MT-4 cells, l -lysine-α-oxidase, an inhibitor of HIV reproduction, selectively inhibits the synthesis of histone proteins, including 18K antigen (H2B histone). This protein is the target for autoimmune suppression of helper T cells. The enzyme has a low effect on the synthesis of other proteins and DNA. In addition to 18K antigen, l -lysine-α-oxidase suppresses the synthesis of high-molecular-weight proteins (270, 220, 140, 100, 75, 70, and 60 kD).



Bulletin of Experimental Biology and MedicineSpringer Journals

Published: Jan 1, 1997

DOI: 10.1007/BF02764371

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